Emerging Roles of BAI Adhesion-GPCRs in Synapse Development and Plasticity.
Emerging Roles of BAI Adhesion-GPCRs in Synapse Development and Plasticity.
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DOI：
10.1155/2016/8301737
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发表时间：
2016
影响因子：
3.1
通讯作者：
Tolias KF
中科院分区：
文献类型：
--
作者：
Duman JG;Tu YK;Tolias KF
突触调节神经元之间的通信，使大脑能够对经验做出反应，这对学习和记忆至关重要。大脑中大多数兴奋性突触的位置，树突棘，经历了快速重塑，这对神经回路的形成和突触的可塑性是重要的。突触和脊柱形成以及可塑性的异常与一系列大脑疾病有关，包括智力残疾、自闭症谱系障碍(ASD)和精神分裂症。因此，阐明调节这些神经元过程的机制对于了解大脑功能和疾病至关重要。脑特异性血管生成抑制因子(BAI)亚家族黏附G蛋白偶联受体(黏附-GPCRs)是近年来出现的突触发育和可塑性的中枢调节因子。在这篇综述中，我们将总结目前关于Bais在突触中的作用的知识，重点介绍它们的调节、下游信号和生理功能，同时注意到其他黏附-GPCRs在突触中的作用。我们还将讨论Bais在各种神经和精神疾病中的相关性，并考虑它们作为治疗这些疾病的药理靶点的潜在重要性。
Synapses mediate communication between neurons and enable the brain to change in response to experience, which is essential for learning and memory. The sites of most excitatory synapses in the brain, dendritic spines, undergo rapid remodeling that is important for neural circuit formation and synaptic plasticity. Abnormalities in synapse and spine formation and plasticity are associated with a broad range of brain disorders, including intellectual disabilities, autism spectrum disorders (ASD), and schizophrenia. Thus, elucidating the mechanisms that regulate these neuronal processes is critical for understanding brain function and disease. The brain-specific angiogenesis inhibitor (BAI) subfamily of adhesion G-protein-coupled receptors (adhesion-GPCRs) has recently emerged as central regulators of synapse development and plasticity. In this review, we will summarize the current knowledge regarding the roles of BAIs at synapses, highlighting their regulation, downstream signaling, and physiological functions, while noting the roles of other adhesion-GPCRs at synapses. We will also discuss the relevance of BAIs in various neurological and psychiatric disorders and consider their potential importance as pharmacological targets in the treatment of these diseases.