Target Range of Zwittermicin A, an Aminopolyol Antibiotic from Bacillus cereus
Target Range of Zwittermicin A, an Aminopolyol Antibiotic from Bacillus cereus
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DOI：
10.1007/s002849900328
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发表时间：
1998-07
影响因子：
2.6
通讯作者：
L. Silo-suh;E. Stabb;S. Raffel;J. Handelsman
中科院分区：
文献类型：
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作者：
L. Silo-suh;E. Stabb;S. Raffel;J. Handelsman
Zwittermicin A是由蜡样芽孢杆菌（bacillus cereusUW85）产生的一种新型抗生素，在实验室和田间均具有抑制某些植物病害的作用。我们建立了一种快速、大规模纯化两性霉素a的方法，并研究了两性霉素a对细菌、真菌和原生生物的体外活性。Zwittermicin A对卵菌及其亲缘关系藻类原生生物具有高活性，对多种革兰氏阴性菌和某些革兰氏阳性菌以及多种植物病原真菌具有中等活性。Zwittermicin A在pH 7 ~ 8比pH 5 ~ 6对细菌和真菌更有活性。当两性霉素A与另一种由b产生的抗生素kanosamine联合使用时。二者对大肠杆菌有协同作用，对卵霉菌疫霉有附加作用。结果表明，这类新型抗生素具有多种潜在的应用前景。
Zwittermicin A is a novel antibiotic produced byBacillus cereusUW85, which suppresses certain plant diseases in the laboratory and in the field. We developed a rapid method for large-scale purification of zwittermicin A and then studied the in vitro activity of zwittermicin A against bacteria, fungi, and protists. Zwittermicin A was highly active against the Oomycetes and their relatives, the algal protists, and had moderate activity against diverse Gram-negative bacteria and certain Gram-positive bacteria as well as against a wide range of plant pathogenic fungi. Zwittermicin A was more active against bacteria and fungi at pH 7–8 than at pH 5–6. When zwittermicin A was combined with kanosamine, another antibiotic produced byB. cereus, the two acted synergistically againstEscherichia coliand additively againstPhytophthora medicaginis, an Oomycete. The results indicate that there are diverse potential applications of this new class of antibiotic.