Perilla Oil Has Similar Protective Effects of Fish Oil on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Gut Dysbiosis.
Perilla Oil Has Similar Protective Effects of Fish Oil on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Gut Dysbiosis.
复制标题
紫苏油对高脂饮食引起的非酒精性脂肪肝和肠道菌群失调具有与鱼油相似的保护作用
DOI：
10.1155/2016/9462571
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发表时间：
2016
影响因子：
--
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Tian Y;Wang H;Yuan F;Li N;Huang Q;He L;Wang L;Liu Z
非酒精性脂肪性肝病（NAFLD）是发达国家最常见的慢性肝病。最近的研究表明，肠道微生物群的改变在从简单脂肪变性到脂肪性肝炎的进展中发挥着重要作用。流行病学研究表明，食用富含n-3多不饱和脂肪酸（PUFA）的鱼油或紫苏油可以预防NAFLD。然而，其潜在机制仍不清楚。本研究采用16 s rRNA扩增子测序技术研究鱼油和紫苏油对高脂饮食（HFD-）诱导的非酒精性脂肪肝大鼠肠道菌群的影响。鱼油和紫苏油均改善HFD诱导的肝脂肪变性和炎症。与低脂对照饮食相比，HFD喂养显著降低了肠道中革兰氏阳性菌的相对丰度，鱼油或紫苏油略微逆转了这一点。此外，鱼油和紫苏油消耗消除了HFD喂养动物肠道中普雷沃氏菌和埃希氏菌丰度的升高。有趣的是，与HFD组相比，仅在喂食鱼油的动物中抗肥胖Akkermansia的相对丰度显著增加。总之，与鱼油相比，紫苏油对HFD诱导的NAFLD和肠道生态失调具有相似但略弱的效力。
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in developed countries. Recent studies indicated that the modification of gut microbiota plays an important role in the progression from simple steatosis to steatohepatitis. Epidemiological studies have demonstrated consumption of fish oil or perilla oil rich in n-3 polyunsaturated fatty acids (PUFAs) protects against NAFLD. However, the underlying mechanisms remain unclear. In the present study, we adopted 16s rRNA amplicon sequencing technique to investigate the impacts of fish oil and perilla oil on gut microbiomes modification in rats with high-fat diet- (HFD-) induced NAFLD. Both fish oil and perilla oil ameliorated HFD-induced hepatic steatosis and inflammation. In comparison with the low-fat control diet, HFD feeding significantly reduced the relative abundance of Gram-positive bacteria in the gut, which was slightly reversed by either fish oil or perilla oil. Additionally, fish oil and perilla oil consumption abrogated the elevated abundance of Prevotella and Escherichia in the gut from HFD fed animals. Interestingly, the relative abundance of antiobese Akkermansia was remarkably increased only in animals fed fish oil compared with HFD group. In conclusion, compared with fish oil, perilla oil has similar but slightly weaker potency against HFD-induced NAFLD and gut dysbiosis.