Serum laminin and hyaluronan in liver cirrhosis: Markers of progression with high prognostic value
Serum laminin and hyaluronan in liver cirrhosis: Markers of progression with high prognostic value
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DOI：
10.1016/s0168-8278(96)80239-x
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发表时间：
1996-11-01
影响因子：
25.7
通讯作者：
Gressner, AM
中科院分区：
文献类型：
--
作者：
Korner, T;Kropf, J;Gressner, AM
背景/目标：在一项平均随访12.5+/-3.5个月的前瞻性研究中，我们研究了血清中细胞外基质成分层粘连蛋白和透明质酸在门脉高压症和进行性肝硬化临床严重并发症中的诊断价值。方法：在38例肝纤维化（n=4）和肝硬化患者中结果：门静脉高压与层粘连蛋白（LN）、透明质酸（HA）均无明显相关性，但两者均显著升高（P < 0. 05）。门静脉高压与LN、HA的相关性不显著（P > 0. 05）。门静脉高压与LN、HA的相关性不显著（P > 0. 05）。
Background/Aims: In a prospective study with a mean follow-up period of 12.5+/-3.5 months, we investigated the extracellular matrix components laminin and hyaluronan in serum for their diagnostic value in portal hypertension and in clinically severe complications of progressive liver cirrhosis.Methods: In 38 patients with liver fibrosis (n=4) and cirrhosis (Child A: n=17, B: n=7, C: n=10), the serum concentrations of laminin and hyaluronan were determined, Portal hypertension was assessed by endoscopic control of the esophageal varices and by Doppler sonography of the portal blood flow.Results: Neither laminin nor hyaluronan correlated with portal hypertension, but highly significantly increased (p