IMMUNOHISTOCHEMICAL CHARACTERIZATION OF THE SHELL AND CORE TERRITORIES OF THE NUCLEUS-ACCUMBENS IN THE RAT
IMMUNOHISTOCHEMICAL CHARACTERIZATION OF THE SHELL AND CORE TERRITORIES OF THE NUCLEUS-ACCUMBENS IN THE RAT
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DOI：
10.1111/j.1460-9568.1994.tb00315.x
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发表时间：
1994-08-01
影响因子：
3.4
通讯作者：
GROENEWEGEN, HJ
中科院分区：
文献类型：
--
作者：
JONGENRELO, AL;VOORN, P;GROENEWEGEN, HJ
大鼠的延髓核被分成壳核和核核亚部。尽管积累了伏隔核这种分裂的证据，但这些区域尚未在整个伏隔核的嘴尾侧范围内划定。在本研究中，已试图划定壳和核心使用的分布钙结合蛋白的免疫反应，P物质的免疫反应和乙酰胆碱酯酶活性的横截面和水平截面通过延髓核。结果发现，钙结合蛋白的免疫反应性的模式提供了最明确的标准划分成腹侧和内侧，周边壳显示低至中度的免疫染色，和一个更横向和背侧位于，强烈染色的内核。在大部分地区的核，边界中看到的钙结合蛋白免疫反应模式也可以识别的P物质免疫反应和乙酰胆碱酯酶活性的分布。它的结论是，壳占据了大部分的吻部的核的喙，而喙的核心只代表在最外侧的部分。所有三种标记物的染色强度的差异表明壳和核都具有异质结构。在本研究中，钙结合蛋白的免疫反应性表明，连接模式似乎支持核的分裂。
The nucleus accumbens in the rat has been parcelled into shell and core subdivisions. Despite accumulating evidence for such a division of the nucleus accumbens, these territories have not been delineated throughout the rostrocaudal extent of the nucleus. In the present study, an attempt has been made to delineate the shell and core using the distribution of calcium-binding protein immunoreactivity, substance P immunoreactivity and acetylcholinesterase activity in transverse and horizontal sections through the nucleus accumbens. It was found that the pattern of calcium-binding protein immunoreactivity provides the most unequivocal criterion to divide the nucleus accumbens into a ventral and medial, peripheral shell displaying low to moderate immunostaining, and a more laterally and dorsally located, strongly stained inner core. In most parts of the nucleus, borders seen in the calcium-binding protein immunoreactivity pattern can also be recognized in the distributions of substance P immunoreactivity and acetylcholinesterase activity. It is concluded that the shell occupies most of the rostral part of the nucleus accumbens, whereas rostrally the core is represented only in the most lateral part. Differences in staining intensities for all three markers indicate that both the shell and core have a heterogeneous structure. Patterns of connectivity appear to support the division of the nucleus accumbens as indicated by calcium-binding protein immunoreactivity in the present study.