Maturation arrest of human oocytes as a cause of infertility
Maturation arrest of human oocytes as a cause of infertility
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DOI：
10.1093/humrep/17.6.1604
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发表时间：
2002-06-01
影响因子：
6.1
通讯作者：
Weissman, A
中科院分区：
文献类型：
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作者：
Levran, D;Farhi, J;Weissman, A
人卵母细胞成熟阻滞可能发生在细胞周期的各个阶段。在辅助受孕周期中，很少观察到人类卵母细胞完全无法完成减数分裂。我们在这里描述了一个不育夫妇的病例系列，他们所有的卵母细胞在IVF/ICSI期间反复未能成熟。8对夫妇均表现为不明原因的不孕症，接受了控制卵巢刺激，随后进行了卵母细胞提取和IVF/ICSI。卵母细胞在ICSI前剥离积云细胞，确定其成熟状态。在每对夫妇中，卵母细胞的成熟在生发囊泡（GV） （n = 1）、中期I (MI) （n = 4）和中期II (MII) （n = 3）阶段反复停止。卵母细胞成熟停滞可能是一些以前被归类为不明原因不孕症的夫妇不孕的原因。认识到卵母细胞成熟阻滞是一种特殊的医学状况，可能有助于描述目前被称为“卵母细胞因子”的尚未明确定义的实体。引起卵母细胞成熟阻滞的细胞和遗传机制有待进一步研究。
Maturation arrest of human oocytes may occur at various stages of the cell cycle. A total failure of human oocytes to complete meiosis is rarely observed during assisted conception cycles. We describe here a case series of infertile couples for whom all oocytes repeatedly failed to mature during IVF/ICSI. Eight couples, all presenting with unexplained infertility, underwent controlled ovarian stimulation followed by oocyte retrieval and IVF/ICSI. The oocytes were stripped of cumulus cells prior to the ICSI procedure and their maturity status was defined. In each couple, oocyte maturation was repeatedly arrested at the germinal vesicle (GV) (n = 1), metaphase I (MI) (n = 4) and metaphase II (MII) (n = 3) stage. Oocyte maturation arrest may be the cause of infertility in some couples previously classified as having unexplained infertility. The recognition of oocyte maturation arrest as a specific medical condition may contribute to the characterization of the yet poorly defined entity currently known as `oocyte factor'. The cellular and genetic mechanisms causing oocyte maturation arrest should be the subject of further investigation.