Relationships among alcoholic liver disease, antioxidants, and antioxidant enzymes
Relationships among alcoholic liver disease, antioxidants, and antioxidant enzymes
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DOI：
10.3748/wjg.v22.i1.37
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发表时间：
2016-01-07
影响因子：
4.3
通讯作者：
Fukushima, Michihiro
中科院分区：
文献类型：
--
作者：
Han, Kyu-Ho;Hashimoto, Naoto;Fukushima, Michihiro
过量饮用酒精饮料是世界范围内肝脏疾病的严重原因。乙醇代谢产生的活性氧在酒精性肝病(ALD)的恶化中起着重要作用。抗氧化性植物化学物质，如多酚，调节ALD相关蛋白和多肽的表达，即过氧化氢酶、超氧化物歧化酶、谷胱甘肽、谷胱甘肽过氧化物酶和谷胱甘肽还原酶。这些植物抗氧化剂具有亲电活性，可能通过Kelchlike ECH相关蛋白1-NF-E2相关因子-2途径和抗氧化反应元件诱导抗氧化酶。此外，据报道，这些抗氧化剂可以减轻氧化剂或炎性细胞因子引起的细胞损伤。这些现象可能是通过植物抗氧化剂对丝裂原活化蛋白激酶(MAPK)通路的调节而诱导的，类似于缺血再灌注模型中的预适应。虽然植物抗氧化剂与ALD之间的关系尚未得到充分研究，但植物抗氧化剂可能由于其在MAPK途径中的亲电和调节活性而对ALD起到预防作用。
Excessive consumption of alcoholic beverages is a serious cause of liver disease worldwide. The meta-bolism of ethanol generates reactive oxygen species, which play a significant role in the deterioration of alcoholic liver disease (ALD). Antioxidant phytochemicals, such as polyphenols, regulate the expression of ALD-associated proteins and peptides, namely, catalase, superoxide dismutase, glutathione, glutathione peroxidase, and glutathione reductase. These plant antioxidants have electrophilic activity and may induce antioxidant enzymes via the Kelchlike ECH-associated protein 1-NF-E2-related factor-2 pathway and antioxidant responsive elements. Furthermore, these antioxidants are reported to alleviate cell injury caused by oxidants or inflammatory cytokines. These phenomena are likely induced via the regulation of mitogen-activating protein kinase (MAPK) pathways by plant antioxidants, similar to preconditioning in ischemia-reperfusion models. Although the relationship between plant antioxidants and ALD has not been adequately investigated, plant antioxidants may be preventive for ALD because of their electrophilic and regulatory activities in the MAPK pathway.