Effects of Leisure-Time and Transport-Related Physical Activities on the Risk of Incident and Recurrent Myocardial Infarction and Interaction With Traffic-Related Air Pollution: A Cohort Study.
Effects of Leisure-Time and Transport-Related Physical Activities on the Risk of Incident and Recurrent Myocardial Infarction and Interaction With Traffic-Related Air Pollution: A Cohort Study.
复制标题
DOI：
10.1161/jaha.118.009554
复制
发表时间：
2018-07-18
影响因子：
5.4
通讯作者：
Andersen ZJ
中科院分区：
文献类型：
--
作者：
Kubesch NJ;Therming Jørgensen J;Hoffmann B;Loft S;Nieuwenhuijsen MJ;Raaschou-Nielsen O;Pedersen M;Hertel O;Overvad K;Tjønneland A;Prescot E;Andersen ZJ
体力活动增加了对空气污染物的吸收，可能会减少其有益影响。我们研究了休闲时间和交通相关的体力活动对心肌梗死（MI）风险的影响，以及暴露于交通相关的空气污染是否会降低MI的潜在益处。来自丹麦饮食、癌症和健康队列的57053名参与者（50-65岁）在基线（1993-1997年）报告了体力活动，并与截至2015年12月的MI导致的医院接触和院外死亡的登记数据相关联。在参与者的基线住所估计二氧化氮水平。我们使用考克斯回归将参与运动、骑自行车、散步和园艺与心肌梗死事件和复发联系起来，并通过二氧化氮检测相互作用。在基线时未发生MI的50635例参与者中，2936例发生了MI事件，在基线前发生MI的1233例参与者中，324例在随访期间复发了MI。基线时（1993-1997年）平均二氧化氮浓度为18.7微克/立方米。我们发现参与体育运动（风险比; 95%置信区间：0.85; 0.79-0.92）、骑自行车（0.91; 0.84-0.98）、园艺（0.87; 0.80-0.95）和MI事件之间存在统计学显著负相关，而与步行的相关性在统计学上不显著（0.95; 0.83-1.08）。复发性MI与骑自行车（0.80; 0.63-1.02）、步行（0.82，0.57-1.16）和园艺（0.91; 0.71-1.18）呈统计学非显著负相关，与运动（1.06; 0.83-1.35）呈正相关。二氧化氮对体力活动和心肌梗死之间的关系没有影响。身体活动对MI发病率和复发的益处不会因暴露于高水平的空气污染而减少。
Physical activity enhances the uptake of air pollutants, possibly reducing its beneficial effects. We examined the effects of leisure‐time and transport‐related physical activities on the risk of myocardial infarction (MI), and whether potential benefits on MI are reduced by exposure to traffic‐related air pollution. A group of 57 053 participants (50–65 years of age) from the Danish Diet, Cancer, and Health cohort reported physical activity at baseline (1993–1997) and were linked to registry data on hospital contacts and out‐of‐hospital deaths caused by MI, until December 2015. Nitrogen dioxide levels were estimated at participants’ baseline residences. We used Cox regressions to associate participation in sports, cycling, walking, and gardening with incident and recurrent MI, and tested for interaction by nitrogen dioxide. Of 50 635 participants without MI at baseline, 2936 developed incident MI, and of 1233 participants with MI before baseline, 324 had recurring MI during follow‐up. Mean nitrogen dioxide concentration was 18.7 μg/m3 at baseline (1993–1997). We found inverse statistically significant associations between participation in sports (hazard ratio; 95% confidence interval: 0.85; 0.79–0.92), cycling (0.91; 0.84–0.98), gardening (0.87; 0.80–0.95), and incident MI, while the association with walking was statistically nonsignificant (0.95; 0.83–1.08). Recurrent MI was statistically nonsignificantly inversely associated with cycling (0.80; 0.63–1.02), walking (0.82, 0.57–1.16), and gardening (0.91; 0.71–1.18), and positively with sports (1.06; 0.83–1.35). There was no effect modification of the associations between physical activity and MI by nitrogen dioxide. Benefits of physical activity on both the incidence and the recurrence of MI are not reduced by exposure to high levels of air pollution.