Hb Hope [beta136(H14)Gly-->Asp (GGT-->GAT)]: interactions with Hb S [beta6(A3)Glu-->Val (GAG-->GTG)], other variant hemoglobins and thalassemia.
Hb Hope [beta136(H14)Gly-->Asp (GGT-->GAT)]: interactions with Hb S [beta6(A3)Glu-->Val (GAG-->GTG)], other variant hemoglobins and thalassemia.
复制标题
Hb Hope [beta136(H14)Gly-->Asp (GGT-->GAT)]：与 Hb S [beta6(A3)Glu-->Val (GAG-->GTG)]、其他变异血红蛋白和地中海贫血相互作用。
DOI：
10.1081/hem-200037801
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发表时间：
2004
期刊：
影响因子：
1
通讯作者：
Steinberg,MartinH
中科院分区：
文献类型：
--
作者：
Ingle,John;Adewoye,Adeboye;Dewan,Robert;Okoli,Michael;Rollins,Lamarr;Eung,ShawnH;Luo,Hong-Yuan;Chui,DavidHK;Steinberg,MartinH
Hb Hope [β136(H14)Gly→Asp (GGT→GAT)] was first described in an African–American family in 1965. Since then, it has been found in combination with several different globin gene mutations in many other families of divergent ethnic backgrounds. The basis for its relatively frequent occurrences remains unexplained. This variant hemoglobin (Hb) is mildly unstable and has reduced oxygen affinity, but is generally innocuous clinically. This variant Hb can present as a confounding factor in arriving at a correct diagnosis by either electrophoresis or high performance liquid chromatography (HPLC), particularly during the neonatal period. DNA‐based diagnostics can help solve this potential problem.
