Increase of acetylcholine release from cortex of freely moving rats by administration of histamine into the nucleus basalis magnocellularis
Increase of acetylcholine release from cortex of freely moving rats by administration of histamine into the nucleus basalis magnocellularis
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DOI：
10.1007/s000110050254
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发表时间：
1998
影响因子：
6.7
通讯作者：
M. Cecchi;M. Giorgetti;L. Bacciottini;M. Giovannini;P. Blandina
中科院分区：
文献类型：
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作者：
M. Cecchi;M. Giorgetti;L. Bacciottini;M. Giovannini;P. Blandina
通过激活大脑皮层组胺H3受体，组胺已被证明可以抑制体内大鼠大脑皮层的乙酰胆碱释放[1]。这种效应是间接的，由皮质GABA中间神经元介导[2]。然而，在体外，为大脑皮层提供胆碱能神经支配的胆碱能基底核大细胞(NBM)神经元受到组胺的兴奋[4]。因此，组胺能神经元也可能促进皮质胆碱能活动。本研究在大鼠体内研究了NBM的组胺能/胆碱能相互作用。
Through the activation of cortical histamine H3 receptors, histamine has been shown to inhibit acetylcholine release from rat cortex in vivo [1]. This effect is indirect, mediated by cortical GABA interneurons [2]. However, cholinergic nucleus basalis magnocellularis (NBM) neurons, which provide cholinergic innervation to the cortex [3], are excited by histamine in vitro [4]. Thus, histaminergic neurons might also facilitate cortical cholinergic activity. This study investigated NBM histaminergic/cholinergic interactions in vivo in the rat.