Effect of Calcium Channel Blockers on Serotonin Uptake
Effect of Calcium Channel Blockers on Serotonin Uptake
复制标题
钙通道阻滞剂对血清素摄取的影响
DOI：
10.3181/00379727-193-43043
复制
发表时间：
1990
影响因子：
--
通讯作者：
B. Fanburg
中科院分区：
文献类型：
--
作者：
N. Hill;S. Lee;B. Fanburg
Abstract We previously demonstrated that verapamil inhibits serotonin uptake by bovine pulmonary arterial endothelial cells by a mechanism not involving alterations in calcium fluxes. In this study, we determine whether verapamil inhibition of serotonin uptake occurs in other pulmonary cell types (bovine pulmonary artery smooth muscle cells), in cells from other organs and species (rat epididymal endothelial cells), and in intact organs (isolated rat lungs). We also compare the effects of verapamil with those of nifedipine and diltiazem. At concentrations of 10-6 M or greater, verapamil is an inhibitor of serotonin uptake by cultured cells and isolated lungs. Nifedipine and diltiazem are weak inhibitors of serotonin uptake by cultured bovine cells only at suprapharmacologic doses and have no effect on serotonin uptake by isolated lungs. Surprisingly, nifedipine stimulates serotonin uptake by rat epididymal endothelial cells. We conclude that inhibition of serotonin uptake by verapamil is a generalized phenomenon, occurring in a variety of cell types, in intact organs, and in different species that does not occur consistently with other calcium channel blockers.
肺血管对慢性缺氧的反应在大鼠慢性高山病发展中的作用。
DOI：
10.1016/0034-5687(84)90146-4
发表时间：
1984
期刊：
Respiration physiology
影响因子：
--
作者：
Hill,NS;Ou,LC
通讯作者：
Ou,LC
培养物中牛肺动脉内皮细胞对血清素的摄取。
DOI：
10.1152/ajpcell.1986.250.5.c766
发表时间：
1986
期刊：
The American journal of physiology
影响因子：
--
作者：
Lee,SL;Fanburg,BL
通讯作者：
Fanburg,BL
培养物中牛肺动脉内皮细胞对血清素的摄取。
DOI：
10.1152/ajpcell.1986.250.5.c761
发表时间：
1986
期刊：
The American journal of physiology
影响因子：
--
作者：
Lee,SL;Fanburg,BL
通讯作者：
Fanburg,BL