Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men
Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men
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DOI：
10.1136/jnnp.2008.165720
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发表时间：
2009-07-01
影响因子：
11
通讯作者：
Wu, Frederick C. W.
中科院分区：
文献类型：
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作者：
Lee, David M.;Tajar, Abdelouahid;Wu, Frederick C. W.
背景：尽管有证据表明维生素D不足可能与不良认知结果有关，但关于这一主题的研究结果并不一致。这项试验的目的是检验25-羟基维生素D(25(OH)D)水平与欧洲中老年男性认知能力之间的关系。方法：这项基于人群的横断面研究包括来自8个欧洲男性老龄化研究中心的3369名年龄在40-79岁之间的男性。采用Rey-Osterrieth复杂图形(ROCF)测验、卡姆登地形再认记忆(CTRM)测验和数字符号替代测验(DSST)评定认知功能。用放射免疫法测定血清25(OH)D水平。其他评估包括体力活动、功能表现和情绪/抑郁的测量。采用局部加权和线性回归模型探讨认知功能与25(OH)D水平之间的关系。结果：共有3133名男性(平均年龄60+/-11岁)进入分析。平均(+/-SD)25(OH)D浓度为63+/-31nmol/L。在年龄调整的线性回归中，高水平的25(OH)D与ROCF测试(每10nmol/L的Beta=0.096；95%CI 0.049~0.144)、CTRM试验(每10nmol/L的Beta=0.075；95%CI 0.026~0.124)和DST(每10nmol/L的Beta=0.318；95%CI 0.235~0.401)的高分相关。在调整其他混杂因素后，25(OH)D水平仅与短暂性睡眠呼吸暂停评分相关(每10nmol/L的β=0.152；95%可信区间0.051至0.253)。局部加权和样条回归分析表明，当25(OH)D浓度低于35nmol/l时，25(OH)D浓度与认知功能的关系最为显著。结论：在本研究中，较低的25(OH)D水平与较差的认知功能有关。有必要进行进一步的研究，以确定维生素D的充足是否可能在保护老年人的认知功能方面发挥作用。
Background: Although there is evidence that vitamin D inadequacy may be linked to adverse cognitive outcomes, results from studies on this topic have been inconsistent. The aim of this trial was to examine the association between 25-hydroxyvitamin D (25(OH) D) levels and cognitive performance in middle-aged and older European men.Methods: This population-based cross-sectional study included 3,369 men aged 40-79 years from eight centres enrolled in the European Male Ageing Study. Cognitive function was assessed using the Rey-Osterrieth Complex Figure (ROCF) test, the Camden Topographical Recognition Memory (CTRM) test and the Digit Symbol Substitution Test (DSST). Serum 25(OH) D levels were measured by radioimmunoassay. Additional assessments included measurement of physical activity, functional performance and mood/depression. Associations between cognitive function and 25(OH) D levels were explored using locally weighted and linear regression models.Results: In total, 3,133 men (mean (+/- SD) age 60 +/- 11 years) were included in the analysis. The mean (+/- SD) 25(OH) D concentration was 63 +/- 31 nmol/l. In age-adjusted linear regressions, high levels of 25(OH) D were associated with high scores on the copy component of the ROCF test (beta per 10 nmol/l = 0.096; 95% CI 0.049 to 0.144), the CTRM test (beta per 10 nmol/l= 0.075; 95% CI 0.026 to 0.124) and the DSST (beta per 10 nmol/l = 0.318; 95% CI 0.235 to 0.401). After adjusting for additional confounders, 25(OH) D levels were associated with only score on the DSST (beta per 10 nmol/l = 0.152; 95% CI 0.051 to 0.253). Locally weighted and spline regressions suggested the relationship between 25(OH) D concentration and cognitive function was most pronounced at 25(OH) D concentrations below 35 nmol/l.Conclusion: In this study, lower 25(OH) D levels were associated with poorer performance on the DSST. Further research is warranted to determine whether vitamin D sufficiency might have a role in preserving cognitive function in older adults.