EXPERIMENTAL DIABETES MELLITUS INDUCED BY DIET IN SAND RAT
EXPERIMENTAL DIABETES MELLITUS INDUCED BY DIET IN SAND RAT
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DOI：
10.1152/ajplegacy.1965.208.2.297
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发表时间：
1965-01-01
影响因子：
--
通讯作者：
SCHMIDTN.K
中科院分区：
文献类型：
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作者：
HAINES, H;HACKEL, DB;SCHMIDTN.K
沙鼠（Psammomys obesus），一种来自近东和北非的啮齿动物，在标准实验室饲料中饲养时会患糖尿病。另一方面，在其自然栖息地收集的动物没有显示糖尿病的迹象。12只动物在实验室中以补充有新鲜蔬菜的Purina实验室饲料饲养。这些动物中的大多数发生了严重的糖尿病，如高血糖症、糖尿和病理学病变所示，包括白内障、肥胖和胰岛组织的β细胞脱粒和空泡化。10只完全用新鲜蔬菜饲养的动物保持健康，没有糖尿病的迹象。报告了血浆和尿糖浓度、体重和白内障的发生率。
The sand rat (Psammomys obesus), a rodent from the Near East and North Africa, becomes diabetic when raised on standard laboratory feeds. Animals collected in their natural habitat, on the other hand, show no signs of diabetes mellitus. Twelve animals were raised in the laboratory on Purina laboratory chow supplemented with fresh vegetables. Most of these animals developed severe diabetes mellitus as indicated by hyperglycemia, glucosuria, and pathological lesions including cataracts, obesity, and ß-cell degranulation and vacuolization of the pancreatic islet tissue. Ten animals raised entirely on fresh vegetables remained healthy with no signs of diabetes. Plasma and urine glucose concentrations, body weights, and the occurrence of cataracts are reported.