Prevalence and risk factors for Helicobacter pylori Infection in chinese populations
Prevalence and risk factors for Helicobacter pylori Infection in chinese populations
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DOI：
10.1111/j.1523-5378.2008.00586.x
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发表时间：
2008-04-01
期刊：
影响因子：
4.4
通讯作者：
Zhang, Guoxin
中科院分区：
文献类型：
--
作者：
Shi, Ruihua;Xu, Shunfu;Zhang, Guoxin
背景：发展中国家幽门螺杆菌的患病率较高。本研究的目的是调查H.方法：采用前瞻性流行病学调查方法，对江苏省胃癌高发区的H。在江苏省响水县和高邮县的1457名自然人群中进行了pylori感染。H. pylori感染（C-13-尿素呼气试验和血清抗H.结果：1371例完成问卷调查的受试者中，H. pylori阳性851例（62%）。幽门螺杆菌阳性。30-40岁为患病高峰（67%）。没有性别差异。家庭年收入水平与H.幽门感染H.幽门螺杆菌感染还与家庭规模、教育水平和几个与饮食有关的因素有关，如每周吃米饭和土豆的次数，以及家族胃病史。与无症状的个体相比，有消化不良症状（恶心、呕吐和打嗝）的人的H。幽门感染H.多因素Logistic回归分析显示，家庭年收入和文化程度是H.结论：H.幽门螺杆菌感染存在于胃癌高发区，并与多种危险因素有关。其内在机制有待进一步研究。
Background: The prevalence of Helicobacter pylori is higher in developing countries. The aim of this study was to investigate the prevalence and risk factors of H. pylori infection in areas with high prevalence of gastric cancer in Jiangsu Province, China.Methods: A prospective epidemiologic survey of H. pylori infection was accomplished in a natural population of 1457 individuals in Xiangshui and Gaoyou counties, Jiangsu Province, China. Questionnaires and laboratory tests for H. pylori infection (C-13-urea breath test and serum IgG antibodies to H. pylori) were used and performed, respectively.Result: Among 1371 subjects who completed questionnaires and H. pylori detection, 851 (62%) were H. pylori positive. The prevalence reached a peak at the age of 30-40 years (67%). There was no sex difference. The annual family income level was shown to be positively correlated with the risk of H. pylori infection. The prevalence of H. pylori infection was also associated with family size, education level, and several diet-related factors, such as the number of times cooked rice and potatoes eaten per week, and a family history of stomach diseases. Compared to nonsymptomatic individuals, people with dyspeptic symptoms (nausea, vomiting, and belching) presented a low prevalence of H. pylori infection. No association between H. pylori prevalence and smoking or drinking was found. Using multivariate logistic regression analysis, annual family income and education level were the independent predictors for H. pylori infection.Conclusion: High prevalence of H. pylori infection was found in areas with a high risk of gastric cancer and was related to several risk factors. The underlying mechanisms need to be further investigated.