A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus
A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus
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DOI：
10.1073/pnas.0700741104
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发表时间：
2007-05-08
影响因子：
11.1
通讯作者：
Real, Leslie A.
中科院分区：
文献类型：
--
作者：
Biek, Roman;Henderson, J. Caroline;Real, Leslie A.
新出现的病原体在入侵过程中可能经历快速进化，同时扩大种群规模和地理范围，但通常很难证明这些过程是如何相互作用的。我们对涵盖北美浣熊大规模狂犬病病毒爆发的30年数据集的分析揭示了初始感染浪潮在确定病毒种群在空间中的遗传结构方面的长期影响。我们进一步发现，根据遗传数据得出的基于融合的估计产生了令人惊讶的准确的已知病毒的空间和人口动力学的重建。我们的研究表明，病原体进入一个完全敏感的宿主群体后，它的传播具有进化和种群动力学的组合过程。此外，这些结果提供了关于狂犬病持久性的空间尺度的重要见解，并验证了联合方法的使用，以揭示即使是相对复杂的人口历史。这种方法对于在景观背景下理解新出现的人畜共患疾病的流行病学将具有越来越大的相关性。
Emerging pathogens potentially undergo rapid evolution while expanding in population size and geographic range during the course of invasion, yet it is generally difficult to demonstrate how these processes interact. Our analysis of a 30-yr data set covering a large-scale rabies virus outbreak among North American raccoons reveals the long lasting effect of the initial infection wave in determining how viral populations are genetically structured in space. We further find that coalescent-based estimates derived from the genetic data yielded an amazingly accurate reconstruction of the known spatial and demographic dynamics of the virus overtime. Our study demonstrates the combined evolutionary and population dynamic processes characterizing the spread of pathogen after its introduction into a fully susceptible host population. Furthermore, the results provide important insights regarding the spatial scale of rabies persistence and validate the use of coalescent approaches for uncovering even relatively complex population histories. Such approaches will be of increasing relevance for understanding the epidemiology of emerging zoonotic diseases in a landscape context.