THE PRODUCT OF THE MOS PROTO-ONCOGENE AS A CANDIDATE INITIATOR FOR OOCYTE MATURATION
THE PRODUCT OF THE MOS PROTO-ONCOGENE AS A CANDIDATE INITIATOR FOR OOCYTE MATURATION
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DOI：
10.1126/science.2474853
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发表时间：
1989-08-11
期刊：
影响因子：
56.9
通讯作者：
VANDEWOUDE, GF
中科院分区：
文献类型：
--
作者：
SAGATA, N;DAAR, I;VANDEWOUDE, GF
内源性c-mos产物pp 39 mos是甾体酮诱导非洲爪蟾卵母细胞减数分裂成熟所必需的。用孕酮处理卵母细胞可诱导pp 39 mos的快速增加，这种增加先于成熟促进因子（MPF）的激活和生殖囊泡破裂（GVBD）。将合成的mos RNA显微注射到卵母细胞中激活MPF，并在没有孕酮的情况下诱导GVBD。因此，mos原翁戈基因产物可以作为MPF的候选“起始”蛋白质，并且是G2至M转变的“触发物”中的至少一种。
The endogenous c-mos product, pp39mos, is required for progesterone-induced meiotic maturation in Xenopus oocytes. Treatment of oocytes with progesterone induced a rapid increase in pp39mos that preceded both the activation of maturation promoting factor (MPF) and germinal vesicle breakdown (GVBD). Microinjection of synthetic mos RNA into oocytes activated MPF and induced GVBD in the absence of progesterone. Thus, the mos proto-ongogene product may qualify as a candidate "initiator" protein of MPF and is at least one of the "triggers" for G2 to M transition.