Semantic memory in partial epilepsy: verbal and non-verbal deficits and neuroanatomical relationships
Semantic memory in partial epilepsy: verbal and non-verbal deficits and neuroanatomical relationships
复制标题
DOI：
10.1016/j.neuropsychologia.2004.12.010
复制
发表时间：
2005-01-01
期刊：
影响因子：
2.6
通讯作者：
Avanzini, G
中科院分区：
文献类型：
--
作者：
Giovagnoli, AR;Erbetta, A;Avanzini, G
对 124 名癫痫患者进行了语义记忆评估，其中包括 84 名左颞叶癫痫 (n=44) 或右颞叶癫痫 (TLE) (n=40) 和 40 名左额叶癫痫 (n=25) 或右额叶癫痫 (FLE) (n = 15)，以确定他们的语言和视觉缺陷以及它们之间的神经解剖学关系。对照组是 35 名健康受试者。语义记忆通过图片命名、图片指向、言语金字塔和棕榈树测试 (PPTT)、视觉 PPTT、物体决策困难和凭记忆绘画来评估。通过短篇故事、雷伊复杂图、言语和视觉选择性提醒程序和布朗-彼得森程序来评估情景记忆。癫痫患者的因素分析将他们的语义记忆得分与其他神经心理学领域区分开来。语义记忆因素与癫痫区域的一侧显着相关，左半球和左侧TLE患者得分较低。与对照组相比，左侧 TLE 患者在图片命名、图片指向和物体决策困难方面明显受损。随后的分析表明，与对照组和右侧 TLE 患者相比，具有外侧颞叶病变的左侧 TLE 患者在图片命名方面受损，而与对照组相比，具有内侧颞叶病变的左侧 TLE 患者在对象决策困难方面受损。相反，情景记忆因素与癫痫区域的一侧无关，并且一些特定材料测试显示左右半球患者存在相反的损伤。这些结果表明，左侧TLE可能导致涉及言语和视觉信息的语义记忆缺陷。与情景记忆的特定材料模式不同，这种损伤模式符合非模态语义存储的观点，其中有关事物的所有信息都重叠。语义记忆障碍可能反映了外侧和内侧颞叶区域的损伤，损害了存储和检索信息的新皮质功能或处理有意义刺激的海马功能。 (c) 2005 Elsevier Ltd. 保留所有权利。
Semantic memory was evaluated in 124 epilepsy patients, including 84 with left (n=44) or right temporal lobe epilepsy (TLE) (n=40) and 40 with left (n=25) or right frontal lobe epilepsy (FLE) (n = 15), in order to determine their verbal and visual deficits, and the neuroanatomical relationships between them. The controls were 35 healthy subjects. Semantic memory was assessed by means of Picture Naming, Picture Pointing, the verbal Pyramid and Palm Trees Test (PPTT), the visual PPTT, Object Decision Hard, and Drawing From Memory. Episodic memory was assessed by means of the Short Story, Rey's Complex Figure, the Verbal and,Visual Selective Reminding Procedure and Brown-Peterson Procedure.Factor analysis of the epilepsy patients distinguished their semantic memory scores from other neuropsychological domains. The semantic memory factor was significantly related to the side of the epileptic region, with lower scores in the left hemisphere and left TLE patients. In comparison with the controls, the left TLE patients were significantly impaired on Picture Naming, Picture Pointing, and Object Decision Hard. Subsequent analyses showed that, in comparison with the controls and the right TLE patients, the left TLE patients with lateral temporal lobe lesions were impaired in Picture Naming whereas, in comparison with the controls, the left TLE patients with mesial temporal lobe lesions were impaired in Object Decision Hard. On the contrary, the episodic memory factor was not related to the side of the epileptic region, and a few material-specific tests revealed opposite impairments in the left and right hemisphere patients.These results show that left TLE may cause semantic memory deficits involving verbal and visual information. Unlike the material-specific pattern of episodic memory, this pattern of impairment is in line with the view of an amodal semantic store in which all of the information about a thing overlaps. The semantic memory impairment may reflect damage in the lateral and mesial temporal lobe regions that impair neocortical functions in storing and retrieving information or hippocampal functions in processing meaningful stimuli. (c) 2005 Elsevier Ltd. All rights reserved.