Cytokines and psychopathology:: Lessons from interferon-α
Cytokines and psychopathology:: Lessons from interferon-α
复制标题
DOI：
10.1016/j.biopsych.2004.02.009
复制
发表时间：
2004-12-01
影响因子：
10.6
通讯作者：
Miller, AH
中科院分区：
文献类型：
--
作者：
Capuron, L;Miller, AH
Inteiferon-alpha 是细胞因子网络的有效诱导剂，并且会导致行为改变。对接受干扰素-α治疗的患者的研究揭示了至少两种不同的综合征：1）在干扰素-α治疗期间晚期出现的情绪/认知综合征对抗抑郁药有反应，并且与神经内分泌途径的激活和血清素代谢改变有关；2）以兴奋运动减慢为特征的植物神经综合征，以及在干扰素-α治疗期间早期出现的疲劳是抗抑郁药无反应的，可能是由基底神经节多巴胺代谢的改变。干扰素-α的研究结果可能提供关于细胞因子诱导的医学疾病患者行为变化的病理生理学和治疗的重要线索，同时也可能模拟没有医学疾病的患者神经精神症状的发展。
Inteiferon-alpha is a potent inducer of the cytokine network and is notorious jbr causing behavioral alterations. Studies on inteiferon-alpha-treated patients reveal at least two distinct syndromes: 1) a mood/cognitive syndrome that appears late during interferon-alpha therapy is responsive to antidepressants and is associated with activation of neuroendocrine pathways and altered serotonin metabolism,: and 2) a neurovegetative syndrome characterized by pychomotor slowing, and fatigue that appears early during inteiferon-alpha treatment is antidepressant nonresponsive and may be mediated by alterations in basal ganglia dopamine metabolism. Findings from inteferon-alpha may provide important clues regarding, the pathophysiology and treatment of cytokine-induced behavioral changes in medically ill patients, while also potentially modeling the development of neuropsychiatric symptoms in patients without medical disordcrs.