Rate of Inpatient Weight Restoration Predicts Outcome in Anorexia Nervosa
Rate of Inpatient Weight Restoration Predicts Outcome in Anorexia Nervosa
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DOI：
10.1002/eat.20634
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发表时间：
2009-05-01
影响因子：
5.5
通讯作者：
Johnson, Craig L.
中科院分区：
文献类型：
--
作者：
Lund, Brian C.;Hernandez, Elsa R.;Johnson, Craig L.
目的：为了检查住院治疗期间的体重恢复参数作为神经性厌食症（AN）结果的预测因素：青少年和成年女性住院进食障碍治疗招募了一个正在进行的纵向研究。这项分析研究了几个体重恢复参数与AN.结果：体重增加率的参与者出院后的临床恶化的预测因素是唯一的恢复参数，预测第1年的结果。在每周增重>= 0.8 kg的参与者中，临床恶化的发生率显著降低（12/41，29%）低于此阈值（20/38，53%）（chi（2）= 4.37，df = 1，p = 0.037），在调整潜在混杂因素后仍具有显著性。AN住院治疗期间的体重增加率是出院后短期临床结局的重要预测因素。目前尚不清楚体重增加率是否具有因果关系，或者是准备耐受体重恢复并参与恢复过程的标志。(C)出版社：Wiley Periodicals，Inc.
Objective: To examine weight restoration parameters during inpatient treatment as predictors of outcome in anorexia nervosa (AN).Method: Adolescent and adult females admitted for inpatient eating disorder treatment were recruited for an ongoing longitudinal study. This analysis examined several weight restoration parameters as predictors of clinical deterioration after discharge among participants with AN.Results: Rate of weight gain was the only restoration parameter that predicted year 1 outcome. Clinical deterioration occurred significantly less often among participants who gained >= 0.8 kg/week (12/41, 29%) than those below this threshold (20/38, 53%) (chi(2) = 4.37, df = 1, p = .037) and remained significant after adjustment for potential confounders.Discussion: Weight gain rate during inpatient treatment for AN was a significant predictor of short-term clinical outcome after discharge. it is unclear whether weight gain rate exerts a causal effect or is rather a marker for readiness to tolerate weight restoration and engage in the recovery process. (C) 2008 by Wiley Periodicals, Inc.