Retrosplenial Cortical Neurons Encode Navigational Cues, Trajectories and Reward Locations During Goal Directed Navigation
Retrosplenial Cortical Neurons Encode Navigational Cues, Trajectories and Reward Locations During Goal Directed Navigation
复制标题
DOI：
10.1093/cercor/bhw192
复制
发表时间：
2017-07-01
期刊：
影响因子：
3.7
通讯作者：
Smith, David M.
中科院分区：
文献类型：
--
作者：
Vedder, Lindsey C.;Miller, Adam M. P.;Smith, David M.
脾后皮层（RSC）在记忆和空间导航中起着重要作用。它与海马体在功能上有相似之处，包括在空间导航中存在位置场和损伤性损伤，并且RSC是海马体视觉空间输入的重要来源。最近，RSC一直是人类记忆和导航研究人员密切关注的目标。功能磁共振成像和病变数据表明，RSC在使用地标导航到目标位置的能力中起作用。然而，没有直接的神经生理学证据表明编码导航线索，因此RSC对空间认知的具体贡献一直不确定。为了检验这一点，我们训练大鼠进行t形迷宫任务，在这个任务中，奖励位置由闪烁的光明确提示，我们记录了大鼠学习时的RSC神经元。我们发现RSC神经元快速编码光线索。此外，RSC神经元对奖励及其位置进行编码，它们在到达目标的左右轨迹上显示出不同的放电模式。这些反应可能为目标导向导航提供关键信息，这些信号的丢失可能是RSC损伤受试者导航障碍的基础。
The retrosplenial cortex (RSC) plays an important role in memory and spatial navigation. It shares functional similarities with the hippocampus, including the presence of place fields and lesion-induced impairments in spatial navigation, and the RSC is an important source of visual-spatial input to the hippocampus. Recently, the RSC has been the target of intense scrutiny among investigators of human memory and navigation. fMRI and lesion data suggest an RSC role in the ability to use landmarks to navigate to goal locations. However, no direct neurophysiological evidence of encoding navigational cues has been reported so the specific RSC contribution to spatial cognition has been uncertain. To examine this, we trained rats on a T-maze task in which the reward location was explicitly cued by a flashing light and we recorded RSC neurons as the rats learned. We found that RSC neurons rapidly encoded the light cue. Additionally, RSC neurons encoded the reward and its location, and they showed distinct firing patterns along the left and right trajectories to the goal. These responses may provide key information for goal-directed navigation, and the loss of these signals may underlie navigational impairments in subjects with RSC damage.