Autonomic neuropathy is associated with increased cardiovascular risk factors:: the EURODIAB IDDM Complications Study
Autonomic neuropathy is associated with increased cardiovascular risk factors:: the EURODIAB IDDM Complications Study
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DOI：
10.1046/j.1464-5491.2002.00821.x
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发表时间：
2002-11-01
影响因子：
3.5
通讯作者：
Fuller, JH
中科院分区：
文献类型：
--
作者：
Kempler, P;Tesfaye, S;Fuller, JH
目的评估EURODIAB IDDM并发症研究中自主神经病变的患病率和危险因素。方法该研究涉及从16个欧洲国家的31个中心随机选择的I型（胰岛素依赖型）糖尿病患者进行检查。神经病变症状和自主神经功能的两个测试（心率和血压的变化，从躺到站）进行了评估，并从3007例患者的数据可用于本分析。自主神经病变定义为至少一项检查异常。结果自主神经病变的患病率为36%，无性别差异。1次和2次反射试验异常的频率分别为30%和6%。24%的患者R-R比值异常，而18%的患者有直立性低血压，定义为站立时收缩压下降> 20 mmHg。自主神经病变与年龄有显著相关性（P
Aims To assess the prevalence of and risk factors for autonomic neuropathy in the EURODIAB IDDM Complications Study.Methods The study involved the examination of randomly selected Type I (insulin-dependent) diabetic patients from 31 centres in 16 European countries. Neuropathic symptoms and two tests of autonomic function (changes in heart rate and blood pressure from lying to standing) were assessed and data from 3007 patients were available for the present analysis. Autonomic neuropathy was defined as an abnormality of at least one of the tests.Results The prevalence of autonomic neuropathy was 36% with no sex differences. The frequency of one and two abnormal reflex tests was 30% and 6%, respectively. The R-R ratio was abnormal in 24% of patients while 18% had orthostatic hypotension defined as a fall in systolic blood pressure > 20 mmHg on standing. Significant correlations were observed between autonomic neuropathy and age (P