High prevalence and increased severity of pathology of bovine tuberculosis in Holsteins compared to zebu breeds under field cattle husbandry in central Ethiopia
High prevalence and increased severity of pathology of bovine tuberculosis in Holsteins compared to zebu breeds under field cattle husbandry in central Ethiopia
复制标题
DOI：
10.1128/cvi.00205-07
复制
发表时间：
2007-10-01
影响因子：
--
通讯作者：
Vordermeier, Martin
中科院分区：
文献类型：
--
作者：
Ameni, Gobena;Aseffa, Abraham;Vordermeier, Martin
对饲养在埃塞俄比亚中部高地牧场上的5424头牛（2578头斑马、1921头杂交和925头荷斯坦）进行了牛结核病（TB）患病率和病理学的比较研究，采用比较皮内结核菌素试验、死后检查和细菌学方法。牛结核总患病率为13.5%；荷斯坦犬的患病率高于斑马(22.2%比11.6%,chi(2) = 61.8；P < 0.001)或交叉(22.2%对11.9%,chi(2) = 50.7；P < 0.001)。此外，荷斯坦犬的病理严重程度（平均+/-标准误差[SEM]， 6.84 +/- 0.79）显著高于斑马的病理严重程度（5.21 +/- 0.30）（P = 0.018）。此外，荷斯坦犬患TB的风险是斑马犬的两倍多（优势比[OR] = 2.32； 95%可信区间[CI] = 1.89, 2.85）。5 - 9岁的动物患牛结核病的风险高于2岁的动物（OR = 2.37; 95% CI = 1.80, 3.12）。P < 0.001)淋巴结结核病变发生的年龄及以下。记录的显著差异；肠系膜淋巴结（平均病理评分SEM， 1.95 +/- 0.08）受影响最严重，其次是咽后淋巴结（0.80 +/- 0.05）和尾纵隔淋巴结（0.8 +/- 0.06）。56% （n = 145）有结核大体病变的动物培养阳性；培养阳性率最低的部位为皮肤病变（27.3%）和肠系膜淋巴结病变（31.5%）。皮肤试验反应和死后结果都表明，在相同的田间饲养条件下（牧场上），荷斯坦牛比斑马对牛结核病的易感性更高。为了提高牛奶产量以满足亚的斯亚贝巴不断增长的人口需求，该地区引进了越来越多的荷斯坦牛，有鉴于此，这些发现强调了对这些牛群实施控制计划的必要性。
A comparative study on the prevalence and pathology of bovine tuberculosis (TB) was conducted on 5,424 cattle (2,578 zebus, 1,921 crosses, and 925 Holsteins), which were kept on pasture in the central highlands of Ethiopia, using a comparative intradermal tuberculin test, postmortem examination, and bacteriology. The overall prevalence of bovine TB was 13.5%; prevalence was higher in Holsteins than either zebus (22.2% versus 11.6%, chi(2) = 61.8; P < 0.001) or crosses (22.2% versus 11.9%, chi(2) = 50.7; P < 0.001). Moreover, the severity of pathology in Holsteins (mean +/- standard error of the mean [SEM], 6.84 +/- 0.79) was significantly higher (P = 0.018) than the severity of pathology in zebus (5.21 +/- 0.30). In addition, the risk of TB in Holsteins was more than twice (odds ratio [OR] = 2.32; 95% confidence interval [CI] = 1.89, 2.85) that in zebus. Animals between 5 and 9 years of age were at higher (OR = 2.37; 95% CI = 1.80, 3.12) risk of bovine TB than those 2 years of (chi(2) = 351; P < 0.001) in the occurrence of TB lesions in lymph nodes was age or below. A significant difference recorded; the mesenteric lymph node (mean pathology score SEM, 1.95 +/- 0.08) was most severely affected, followed by the retropharyngeal (0.80 +/- 0.05) and caudal mediastinal (0.8 +/- 0.06) lymph nodes. Fifty-six percent (n = 145) of the animals with gross TB lesions were culture positive; the lowest culture positivity was recorded in the skin lesions (27.3%) and the lesions of the mesenteric lymph node (31.5%). Both the skin test response and the postmortem findings suggested a higher susceptibility to bovine TB in Holsteins than zebus under identical field husbandry conditions (on pasture). In the light of increased numbers of Holstein cattle introduced into this area to raise milk production to satisfy the needs of Addis Ababa's growing population, these findings highlight the need for a control program in these herds.