In vitro selection of electrochemical peptide probes using bioorthogonal tRNA for influenza virus detection
In vitro selection of electrochemical peptide probes using bioorthogonal tRNA for influenza virus detection
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DOI：
10.1039/c8cc01775a
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发表时间：
2018-05-21
影响因子：
4.9
通讯作者：
Ito, Yoshihiro
中科院分区：
文献类型：
--
作者：
Bahadur, Tara K. C.;Tada, Seiichi;Ito, Yoshihiro
一种电敏感肽探针已开发出从体外选择技术，使用双正交tRNA制备的电反应性非天然氨基酸，3，4-亚乙二氧基噻吩共轭氨基苯丙氨酸。所选择的探针基于信号开启机制定量检测流感病毒。所开发的策略可用于开发针对各种目标的电化学生物传感器。
An electrosensitive peptide probe has been developed from an in vitro selection technique using biorthogonal tRNA prepared with an electroreactive non-natural amino acid, 3,4-ethylenedioxythiophene-conjugated aminophenylalanine. The selected probe quantitatively detected the influenza virus based on a signal turn-on mechanism. The developed strategy could be used to develop electrochemical biosensors toward a variety of targets.