Virus-like particles as antigenic nanomaterials for inducing protective immune responses in the lung.
Virus-like particles as antigenic nanomaterials for inducing protective immune responses in the lung.
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DOI：
10.2217/nnm.14.107
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Douglas T
中科院分区：
文献类型：
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作者：
Rynda-Apple A;Patterson DP;Douglas T
肺部是许多对人类健康危害最大的病原体的主要入口点。肺部遇到的病原体攻击被当地产生的保护性免疫反应所抵消，这种免疫反应可以通过疫苗策略来刺激，以防止病原体感染。在这里，我们讨论使用病毒样颗粒(VLP)，病毒的非病原体衍生物或蛋白质笼结构，来构建利用肺作为免疫刺激部位的新疫苗。VLP的独特之处在于，它们能够被设计成具有近分子水平的细节以及对其组成和结构的了解。本文总结了基于VLP的肺部疫苗的研究进展，并对未来的疫苗开发提出了一些有希望的结果。
The lung is a major entry point for many of the most detrimental pathogens to human health. The onslaught of pathogens encountered by the lung is counteracted by protective immune responses that are generated locally, which can be stimulated through vaccine strategies to prevent pathogen infections. Here, we discuss the use of virus-like particles (VLPs), nonpathogen derivatives of viruses or protein cage structures, to construct new vaccines exploiting the lung as a site for immunostimulation. VLPs are unique in their ability to be engineered with near molecular level detail and knowledge of their composition and structure. A summary of research in developing VLP-based vaccines for the lung is presented that suggests promising results for future vaccine development.