Amniotic fluid defensins: Potential markers of subclinical intrauterine infection
Amniotic fluid defensins: Potential markers of subclinical intrauterine infection
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DOI：
10.1086/514691
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发表时间：
1998-09-01
影响因子：
11.8
通讯作者：
Greig, PC
中科院分区：
文献类型：
--
作者：
Heine, RP;Wiesenfeld, H;Greig, PC
人中性粒细胞肽1-3（防御素）是由活化的中性粒细胞释放的颗粒成分。我们假设，亚临床宫内感染（IUI）的早产（PTL）患者的羊水（AF）防御素水平升高。AF样本来自203例具有不同临床特征的妊娠患者。用酶联免疫吸附试验测定防御素水平。IUI患者的中位AF防御素水平是早产儿和足月对照组的4倍至24倍。在亚临床IUI患者中，AF培养阳性者AF防御素升高程度更高。AF防御素水平随着组织学绒毛膜炎严重程度的增加而呈指数增加。AF防御素水平> 2，500 ng/mL鉴定了88%的AF培养阳性患者，而>400 ng/mL的水平鉴定了85%的所有感染患者。AF防御素水平可准确识别亚临床IUI患者，如AF培养或胎盘组织学阳性所定义。
Human neutrophil peptides 1-3 (defensins) are granule constituents released from activated neutrophils, We hypothesized that amniotic fluid (AF) defensin levels are elevated in preterm labor (PTL) patients with subclinical intrauterine infection (IUI). AF samples were obtained from 203 pregnant patients with varying clinical characteristics. Defensin levels were measured by enzyme-linked immunosorbent assay. Median AF defensin levels were fourfold to 24-fold higher in patients with IUI than in preterm and term controls. Among patients with subclinical IUI, the degree of AF defensin elevation aas greater in those with a positive AF culture. AF defensin levels increased exponentially with increasing severity of histologic chorioamnionitis. An AF defensin level of >2,500 ng/mL identified 88% of patients with a positive AF culture, whereas a lever of >400 ng/mL identified 85% of all infected patients. AF defensin levels accurately identify patients with subclinical IUI, as defined by a positive AF culture or placental histology.