Idiopathic myelofibrosis associated with ulcerative colitis
Idiopathic myelofibrosis associated with ulcerative colitis
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DOI：
10.1080/1042819022386590
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发表时间：
2002-07-01
影响因子：
2.6
通讯作者：
Cervantes, F
中科院分区：
文献类型：
--
作者：
Arellano-Rodrigo, E;Esteve, J;Cervantes, F
报告1例溃疡性结肠炎(UC)患者发展为特发性骨髓纤维化(IM)。UC的初步诊断是通过结肠镜检查和大肠活检，在一个月的腹痛和血性腹泻病史后进行的。患者对泼尼松和美沙拉明的治疗有良好的反应，6个月后出现新的UC发作，并通过治疗成功控制。然而，两年后观察到脾肿大和贫血，外周血中有不等核细胞增多、泪滴细胞、幼稚髓系前体细胞和血清LDH升高，引起了IM的怀疑，骨髓活检证实了这一诊断。本病例代表了IM与自身免疫性疾病的新关联，并支持了一些IM病例可能存在免疫基础的假说。
A patient with ulcerative colitis (UC) who developed idiopathic myelofibrosis (IM) is reported. The initial diagnosis of UC was established by colonoscopy and large bowel biopsy, performed after a one-month history of abdominal pain and bloody diarrhea. The patient showed a favorable response to prednisone and mesalamine treatment and six months later he developed a new episode of UC, which was successfully controlled with treatment. However, two years later splenomegaly and anemia were observed, with aniso-poikilocytosis, tear-drop cells, immature myeloid precursors in the peripheral blood, and increased serum LDH, arising the suspicion of IM, a diagnosis that was confirmed by bone marrow biopsy. The present case represents a new association of IM with an autoimmune disease and gives support to the hypothesis of a possible immune basis of some IM cases.