Characterization of mandibular bones in senile osteoporotic mice.
Characterization of mandibular bones in senile osteoporotic mice.
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老年骨质疏松小鼠下颌骨的特征。
DOI：
10.1080/03008200802325292
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发表时间：
2008
影响因子：
2.9
通讯作者：
Yamauchi,Mitsuo
中科院分区：
文献类型：
--
作者：
Tokutomi,Kentaro;Matsuura,Takashi;Atsawasuwan,Phimon;Sato,Hironobu;Yamauchi,Mitsuo
目前，对颌骨与年龄相关的变化知之甚少。本研究的目的是表征6个月大的老年痴呆症小鼠，SAMP 6，下颌骨，并与年龄匹配的对照组，SAMR 1进行比较。与SAMR 1相比，SAMP 6显示更薄的皮质骨、更低的骨体积和组织不良的胶原基质。SAMP 6的胶原纤维直径明显小于SAMR 1。在SAMP 6中，胶原含量和交联均低于SAMR 1，但主要成熟交联（吡啶啉）与其前体可还原交联（脱氢二羟基赖氨酸正亮氨酸/其酮胺）的比率高于SAMR 1。此外，胶原的赖氨酸羟基化程度在SAMP 6中高于SAMR 1。结果表明，SAMP 6中胶原蛋白的数量和质量均发生了变化，可能是导致下颌骨骨增龄性骨缺损的原因之一。
At present, little is known about the age-related changes in jaw bones. The aim of this study was to characterize the mandibles of 6 month-old senile osteoporotic mice, SAMP6, and compare with those of age-matched controls, SAMR1. In comparison to SAMR1, SAMP6 showed thinner cortical bone, lower bone volume, and poorly organized collagen matrix. The collagen fibril diameter in SAMP6 was significantly smaller than that of SAMR1. In SAMP6 both collagen content and cross-links were lower than those of SAMR1, but the ratio of the major mature cross-link (pyridinoline) to its precursor reducible cross-link (dehydrodihydroxylysinonorleucine/its ketoamine) was higher in comparison to SAMR1. In addition, the extent of lysine hydroxylation of collagen was higher in SAMP6 than that of SAMR1. These results indicate that not only the quantity of collagen but also its quality are altered in SAMP6 and may result in the age-associated osteoporotic defects of mandibles.