Is there a relationship with anomalous insertions of the distal gubernaculum testis and testicular ectopia? Analysis in human fetuses and patients with cryptorchidism
Is there a relationship with anomalous insertions of the distal gubernaculum testis and testicular ectopia? Analysis in human fetuses and patients with cryptorchidism
复制标题
DOI：
10.1097/01.ju.0000070436.98851.46
复制
发表时间：
2003-08-01
影响因子：
6.6
通讯作者：
Sampaio, FJB
中科院分区：
文献类型：
--
作者：
Favorito, LA;Klojda, CAB;Sampaio, FJB
目的：解释睾丸异位最被接受的理论之一是睾丸引带存在多个远端插入点。我们研究了人类胎儿和隐睾患者的睾丸远端插入情况。 材料和方法：我们研究了 163 名妊娠 10 至 35 周的人类胎儿的 326 个睾丸和 101 名隐睾患者（平均年龄 6.4 岁）的 133 个睾丸。借助立体显微镜（放大倍数 2.5 倍），研究了引带远端插入的存在。 Fisher精确检验用于比较2个研究人群。结果：326个胎儿睾丸中，224个（68.7%）位于腹部，45个（13.8%）位于腹股沟，55个（16.9%）位于阴囊。 1 名胎儿 (0.6%) 在妊娠 23 周时双侧睾丸和双侧乳沟均缺失。 133 个隐睾中，17 个（12.8%）位于腹部，92 个（69.2%）位于腹股沟，24 个（18%）位于高位阴囊，3 个（2.3%）位于隐睾。在 324 个胎儿的阴蒂中，我们仅发现 2 个位于耻骨区域的异常远端插入（0.6%）。所有其他远端插入 (99.4%) 均位于通常位置。在 133 个隐睾中，3 个消失的睾丸没有出现可见的结节。在分析的130个引带中，所有引带都插入阴囊区域。结论：在人类胎儿和隐睾患者中，引带远端部分存在异常插入的情况很少见。
Purpose: One of the most accepted theories for explaining testicular ectopia is the existence of multiple distal insertions of the gubernaculum testis. We studied the distal insertions of the gubernaculum in human fetuses and patients with cryptorchidism.Materials and Methods: We studied 326 gubernacula in 163 human fetuses at 10 to 35 weeks of gestation and 133 gubernacula in 101 patients with cryptorchidism (mean age 6.4 years). With the aid of a stereoscopic microscope (2.5 x magnification), the existence of distal insertions of the gubernaculum was investigated. Fisher's exact test was used to compare the 2 study populations.Results: Of 326 fetal testes 224 (68.7%) were abdominal, 45 (13.8%) inguinal and 55 (16.9%) scrotal. In 1 fetus (0.6%) at 23 weeks of gestation both testes and both gubernacula were absent. Among 133 cryptorchid testes 17 (12.8%) were abdominal, 92 (69.2%) inguinal, 24 (18%) high scrotal and 3 (2.3%) evanescent. Of 324 fetal gubernacula present we found only 2 anomalous distal insertions in the pubopenile region (0.6%). All other distal insertions (99.4%) were at the usual location. Of 133 cryptorchid testes the 3 evanescent testes did not present visible gubernacula. Among 130 gubernacula analyzed all were inserted in the scrotal region.Conclusions: The existence of anomalous insertions at the distal portion of the gubernaculum is rare in human fetuses and patients with cryptorchidism.