Sedentary behaviour and risk of mortality from all-causes and cardiometabolic diseases in adults: evidence from the HUNT3 population cohort
Sedentary behaviour and risk of mortality from all-causes and cardiometabolic diseases in adults: evidence from the HUNT3 population cohort
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DOI：
10.1136/bjsports-2012-091974
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发表时间：
2015-06-01
影响因子：
18.4
通讯作者：
Van der Ploeg, Hidde P.
中科院分区：
文献类型：
--
作者：
Chau, Josephine Y.;Grunseit, Anne;Van der Ploeg, Hidde P.
背景 久坐行为是慢性疾病和死亡的潜在危险因素，也就是说，与促进健康的身体活动无关。很少有研究调查与多种久坐行为相关的死亡风险。 目的 研究总久坐时间、看电视时间和职业久坐与全因死亡率和心脏代谢疾病死亡率的前瞻性关联。 方法 将 2006 年至 2008 年北特伦德拉格健康研究 3 (HUNT3) 中 50 817 名 20 岁以上成年人的数据与截至 12 月 31 日的挪威死因登记处相关联2010 年。Cox 比例风险模型检查了与总坐姿时间、看电视和职业坐姿相关的全因死亡率和心脏代谢疾病相关死亡率，并调整了包括体力活动在内的多种潜在混杂因素。结果平均随访 3.3 年（137 315.8 人年）后，记录了 1068 例死亡，其中 388 例与心脏代谢疾病相关。与总坐着时间相关的全因死亡率的 HR 分别为 1.12（95% CI 0.89 至 1.42）、1.18（95% CI 0.90 至 1.57）和 1.65（95% CI 1.24 至 2.21）4-
Background Sedentary behaviour is a potential risk factor for chronic-ill health and mortality, that is, independent of health-enhancing physical activity. Few studies have investigated the risk of mortality associated with multiple contexts of sedentary behaviour.Objective To examine the prospective associations of total sitting time, TV-viewing time and occupational sitting with mortality from all causes and cardiometabolic diseases.Methods Data from 50 817 adults aged >= 20 years from the Nord-Trondelag Health Study 3 (HUNT3) in 2006-2008 were linked to the Norwegian Cause of Death Registry up to 31 December 2010. Cox proportional hazards models examined all-cause and cardiometabolic disease-related mortality associated with total sitting time, TV-viewing and occupational sitting, adjusting for multiple potential confounders including physical activity.Results After mean follow-up of 3.3 years (137 315.8 person-years), 1068 deaths were recorded of which 388 were related to cardiometabolic diseases. HRs for all-cause mortality associated with total sitting time were 1.12 (95% CI 0.89 to 1.42), 1.18 (95% CI 0.90 to 1.57) and 1.65 (95% CI 1.24 to 2.21) for total sitting time 4-