Aging leads to altered microglial function that reduces brain resiliency increasing vulnerability to neurodegenerative diseases.
Aging leads to altered microglial function that reduces brain resiliency increasing vulnerability to neurodegenerative diseases.
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DOI：
10.1016/j.exger.2017.01.027
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发表时间：
2017-08
影响因子：
3.9
通讯作者：
Grimmig B
中科院分区：
文献类型：
--
作者：
Bickford PC;Flowers A;Grimmig B
衰老是许多神经退行性疾病的主要危险因素。因此，了解随着年龄的增长而发生的基本生物学变化，导致大脑对神经退行性疾病（如帕金森病或阿尔茨海默病）的疾病进展或对大脑的损害（如中风或创伤性脑损伤）的适应性降低。显然，这不能治愈疾病本身，但提高大脑对损伤的反应能力可以改善长期结果。这篇综述的重点是研究小胶质细胞随年龄的变化和可能的治疗干预，涉及使用富含多酚的膳食补充剂。
Aging is the primary risk factor for many neurodegenerative diseases. Thus, understanding the basic biological changes that take place with aging that lead to the brain being less resilient to disease progression of neurodegenerative diseases such as Parkinson’s disease or Alzheimer’s disease or insults to the brain such as stroke or traumatic brain injuries. Clearly this will not cure the disease per se, yet increasing the ability of the brain to respond to injury could improve long term outcomes. The focus of this review is examining changes in microglia with age and possible therapeutic interventions involving the use of polyphenol rich dietary supplements.