Influence of sodium homeostasis on dopaminergic modulation of aldosterone, renin, and prolactin secretion in man.
Influence of sodium homeostasis on dopaminergic modulation of aldosterone, renin, and prolactin secretion in man.
复制标题
钠稳态对人类醛固酮、肾素和催乳素分泌的多巴胺能调节的影响。
DOI：
10.1210/jcem-54-1-121
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
R. Catania
中科院分区：
文献类型：
--
作者：
J. Sowers;M. S. Glub;P. Eggena;R. Catania
本研究探讨了钠稳态对正常人血浆醛固酮、肾素和PRL对多巴胺拮抗剂甲氧氯普胺反应的影响。在接受10-meq钠、80-meq钾饮食5天和接受200-meq钠、80-meq饮食5天后评价对甲氧氯普胺的反应。在这两种情况下，受试者在接受甲氧氯普胺治疗时均达到钠平衡状态，这是通过尿钠测量确定的。服用10 meq钠5天后，受试者对甲氧氯普胺的最大绝对增量醛固酮反应（23.2 +/-2.0 ng/dl）显著高于服用200 meq钠5天后（6.6 +/-0.9 ng/dl）（P <0.001）。尽管钠摄入量的影响小于对甲氧氯普胺的醛固酮反应的影响，但在低钠（10 meq）每日摄入量的情况下也观察到更大的PRL和PRA反应（P <0.05）。PRA反应甲氧氯普胺发生晚（45分钟）相比，醛固酮和PRL的反应，这是注意到5分钟后给药，表明多巴胺在调节肾素分泌的间接作用。无活性的总肾素的比例随着钠摄入量的增加而增加。这些数据表明，钠稳态可能会影响多巴胺能调节的肾素，醛固酮和PRL分泌，并可能影响活性和非活性肾素之间的相互关系。
This study examines the effect of sodium homeostasis on the plasma aldosterone, renin, and PRL responses to the dopamine antagonist metoclopramide in normal individuals. Responses to metoclopramide were evaluated after receiving a 10-meq sodium, 80-meq potassium diet for 5 days and after receiving a 200-meq sodium, 80-meq diet for 5 days. On both occasions, the subjects had reached sodium equilibrium states, as determined by urinary sodium measurements, at the time that they received metoclopramide. Maximum absolute incremental aldosterone responses to metoclopramide were considerably greater (P less than 0.001) in the subjects after 5 days on a 10-meq sodium intake (23.2 +/- 2.0 ng/dl) than after 5 days on a 200-meq sodium intake (6.6 +/-0.9 ng/dl). Greater PRL and PRA responses (P less than 0.05) were also noted with low (10 meq) daily sodium intake, although the influence of sodium intake was less than that observed on the aldosterone response to metoclopramide. PRA responses to metoclopramide occur late (45 min) compared to aldosterone and PRL responses, which were noted 5 min after drug administration, suggesting an indirect effect of dopamine in modulating renin secretion. The proportion of total renin which was inactive was greater with the higher sodium intake. These data suggest that sodium homeostasis may influence dopaminergic modulation of renin, aldosterone, and PRL secretion and may effect the interrelationship between active and inactive renin.