High intensity eccentric resistance training decreases bradykinesia and improves quality of life in persons with Parkinson's disease: A preliminary study
High intensity eccentric resistance training decreases bradykinesia and improves quality of life in persons with Parkinson's disease: A preliminary study
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DOI：
10.1016/j.parkreldis.2009.04.009
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发表时间：
2009-12-01
影响因子：
4.1
通讯作者：
LaStayo, Paul C.
中科院分区：
文献类型：
--
作者：
Dibble, Leland E.;Hale, Tessa F.;LaStayo, Paul C.
帕金森病（PD）患者在活动任务中经常表现出运动迟缓。运动迟缓与其他PD相关的运动缺陷可能导致自我报告的生活质量降低，目前，没有研究检查阻力运动作为减少运动迟缓和改善自我报告的生活质量的干预措施的影响。因此，我们研究了轻度至中度PD患者在12周高强度离心阻力运动计划后肌肉力量产生、运动迟缓临床指标和生活质量的变化。将20名特发性PD患者分为实验组或活性对照组。所有参与者在12周的干预期之前和之后进行了测试。实验组在离心式测力计上进行高强度的股四头肌收缩，每周3天，共12周。活动对照组参加了基于证据的PD运动计划。结局变量为股四头肌肌力、临床运动迟缓测量（步态速度、计时起身和行走）和疾病特异性生活质量（帕金森病问卷-39 [PDQ-39]）。使用单独的2（组）× 2（时间段）ANOVA分析数据。结果表明，组间相互作用对步态速度、起身和行走时间以及复合PDQ-39评分有显著的时间效应（p < 0.05）。与积极控制组相比，进行高强度离心阻力训练的患者的肌力、运动迟缓和生活质量得到了更大程度的改善。需要进一步的研究来确定这种类型的训练是否具有长期影响，以及它是否会改变PD患者的活动性和生活质量下降的自然史。(C)2009爱思唯尔有限公司版权所有。
Persons with Parkinson disease (PD) often demonstrate bradykinesia during mobility tasks. Bradykinesia combined with other PD-related movement deficits may contribute to self-reported reductions in quality of life, At this time, no studies have examined the effects of resistance exercise as an intervention to reduce bradykinesia and improve self-reported quality of life. Therefore, we examined changes in muscle force production, clinical measures of bradykinesia, and quality of life following 12 weeks of a high intensity eccentric resistance exercise program in persons with mild to moderate PD. Twenty individuals with idiopathic PD were matched into an experimental or an active control group. All participants were tested prior to and following a 12-week intervention period. The experimental group performed high intensity quadriceps contractions on an eccentric ergometer 3 days a week for 12 weeks. The active control group participated in an evidence based exercise program of PD. The outcome variables were quadriceps muscle force, clinical bradykinesia measures (gait speed, timed up and go) and disease specific quality of life (Parkinson's disease questionairre-39 [PDQ-39]). Data was analyzed using separate 2 (group) x 2 (time period) ANOVAs. Results demonstrated significant time by group interaction effects for gait speed, timed up and go, and the composite PDQ-39 score (p < 0.05). Muscle force, bradykinesia, and QOL were improved to a greater degree in those that performed high intensity eccentric resistance training compared to an active control group. Additional research is needed to determine if this type of training has long-term impact and if it results in an alteration of the natural history of mobility and QOL decline in persons with PD. (C) 2009 Elsevier Ltd. All rights reserved.