Eccentric exercise as an adjuvant to influenza vaccination in humans
Eccentric exercise as an adjuvant to influenza vaccination in humans
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DOI：
10.1016/j.bbi.2006.04.158
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发表时间：
2007-02-01
影响因子：
15.1
通讯作者：
Ring, Christopher
中科院分区：
文献类型：
--
作者：
Edwards, Kate M.;Burns, Victoria E.;Ring, Christopher
在接种疫苗时暴露在急性应激环境中可以增强动物对接种疫苗的免疫反应。这种佐剂策略对人类接种疫苗的效果需要调查。目前的研究采用随机对照试验设计来检验流感疫苗接种前的偏心运动对抗体和细胞介导的反应的影响。60名健康青年(男29名，女31名)对非优势臂进行三角肌和二头肌偏心收缩(运动组)或安静休息(对照组)，6h后在非优势臂接种疫苗。测量臂围和疼痛的变化，以评估运动的生理反应。在接种前以及6周和20周的随访中测量抗体滴度。在接种后8周测量干扰素-γ对整个疫苗体外刺激的反应，这是细胞介导反应的一个指标。男性的干扰素-伽马反应通过锻炼而增强，而女性的抗体滴度通过离心性锻炼而增强，而男性则没有。在偏心运动后，男性的臂围比女性增加得更多，但在报告的疼痛方面没有差异。在运动组中，干扰素-伽马反应与臂围增加的百分比呈正相关。离心运动对男性和女性接种疫苗的反应有不同的影响，女性的抗体反应增强，而男性的细胞介导的反应增强。应进一步探讨疫苗接种部位肌肉的偏心运动作为疫苗接种的一种可能的行为佐剂。(C)2006 Elsevier Inc.保留所有权利。
The immune response to vaccination in animals can be enhanced by exposure to acute stress at the time of vaccination. The efficacy of this adjuvant strategy for vaccination in humans requires investigation. The current study employed a randomised controlled trial design to examine the effects of eccentric exercise prior to influenza vaccination on the antibody and cell-mediated responses. Sixty young healthy adults (29 men, 31 women) performed eccentric contractions of the deltoid and biceps brachii muscles of the non-dominant arm (exercise group) or rested quietly (control group), and were vaccinated 6 h later in the non-dominant arm. Change in arm circumference and pain were measured to assess the physiological response to exercise. Antibody titres were measured pre-vaccination and at 6- and 20-week follow-ups. Interferon-gamma in response to in vitro stimulation by the whole vaccine, an index of the cell-mediated response, was measured 8 weeks post-vaccination. Interferon-gamma responses were enhanced by exercise in men, whereas antibody titres were enhanced by eccentric exercise in women but not in men. Men showed greater increase in arm circumference after eccentric exercise than women but there was no difference in reported pain. The interferon-gamma response was positively associated with the percentage increase in arm circumference among the exercise group. Eccentric exercise exerted differential effects on the response to vaccination in men and women, with enhancement of the antibody response in women, but enhancement of the cell-mediated response in men. Eccentric exercise of the muscle at the site of vaccine administration should be explored further as a possible behavioural adjuvant to vaccination. (c) 2006 Elsevier Inc. All rights reserved.