Biomechanical characterisation of the human nasal cartilages; implications for tissue engineering.
Biomechanical characterisation of the human nasal cartilages; implications for tissue engineering.
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DOI：
10.1007/s10856-015-5619-8
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Butler PE
中科院分区：
文献类型：
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作者：
Griffin MF;Premakumar Y;Seifalian AM;Szarko M;Butler PE
目前使用自体移植物进行鼻重建提供但受限于供体部位发病率、组织可用性和潜在的移植物失败。此外，目前的替代异体材料受到其高挤出率和感染率的限制。将合成材料的机械性能与它们所替代的天然组织相匹配已被证明在植入物的生物相容性中是重要的。迄今为止，人类鼻软骨的机械性能尚未被深入研究，以能够创建具有与天然组织相似的机械性能的组织工程替代物。杨氏模量的特点是在压缩新鲜冷冻的人尸体隔，骨，和侧软骨。由于中隔软骨的各个方面所经历的功能差异，对16个区域进行了评价，平均弹性模量为2.72 ± 0.63 MPa。此外，发现后隔比前隔明显更硬（p < 0.01）。在四个点测试了内侧和外侧软骨的弹性模量，其范围为2.09 ± 0.81MPa，软骨之间无显著差异（p < 0.78）。所有标本均进行1次侧软骨弹性模量测试，平均弹性模量为0.98 ± 0.29MPa。总之，这项研究提供了新的信息的压缩力学性能的人鼻软骨，使外科医生有一个更好的理解之间的差异的机械性能的个人鼻软骨。本研究为进一步发展组织工程化鼻再造软骨替代物提供了参考。本文的在线版本（doi：10.1007/s10856-015-5619-8）包含补充材料，可供授权用户使用。
Nasal reconstruction is currently performed using autologous grafts provides but is limited by donor site morbidity, tissue availability and potentially graft failure. Additionally, current alternative alloplastic materials are limited by their high extrusion and infection rates. Matching mechanical properties of synthetic materials to the native tissue they are replacing has shown to be important in the biocompatibility of implants. To date the mechanical properties of the human nasal cartilages has not been studied in depth to be able to create tissue-engineered replacements with similar mechanical properties to native tissue. The young’s modulus was characterized in compression on fresh-frozen human cadaveric septal, alar, and lateral cartilage. Due to the functional differences experienced by the various aspects of the septal cartilage, 16 regions were evaluated with an average elastic modulus of 2.72 ± 0.63 MPa. Furthermore, the posterior septum was found to be significantly stiffer than the anterior septum (p < 0.01). The medial and lateral alar cartilages were tested at four points with an elastic modulus ranging from 2.09 ± 0.81 MPa, with no significant difference between the cartilages (p < 0.78). The lateral cartilage was tested once in all cadavers with an average elastic modulus of 0.98 ± 0.29 MPa. In conclusion, this study provides new information on the compressive mechanical properties of the human nasal cartilage, allowing surgeons to have a better understanding of the difference between the mechanical properties of the individual nasal cartilages. This study has provided a reference, by which tissue-engineered should be developed for effective cartilage replacements for nasal reconstruction. The online version of this article (doi:10.1007/s10856-015-5619-8) contains supplementary material, which is available to authorized users.