Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly
Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly
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DOI：
10.1159/000105017
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发表时间：
2007-01-01
影响因子：
2.4
通讯作者：
Londos, Elisabet
中科院分区：
文献类型：
--
作者：
Stomrud, Erik;Hansson, Oskar;Londos, Elisabet
目的：研究脑脊液（CSF）生物标志物是否可以预测健康老年人的认知能力下降，正如它们在认知障碍患者样本中所显示的那样。方法：在本研究中，57名对照者在基线时进行脑脊液生物标志物检测，然后进行为期3年的认知随访。结果：基线β -淀粉样蛋白1 - 42 （A β 42）水平低与影响生活质量的主观记忆障碍（memQoL）的发展有关，随访时迷你精神状态检查评分较差，无法在正常住房中生活（p < 0.05）。基线A β 42和磷酸化tau （P-tau）联合预测病理性memQoL的发展，敏感性为71.4%，特异性为75.7（< 0.01）。结论：低A β 42及A β 42与P-tau联合可预测健康人的主观认知能力下降。总之，本研究表明，在临床正常人群中已经可以检测到阿尔茨海默病相关的生物学体征。版权所有(c) 2007 S. Karger AG，巴塞尔。
Objective: To investigate whether cerebrospinal fluid (CSF) biomarkers can predict cognitive decline in healthy, elderly individuals as they have been shown to do in cognitively impaired patient samples. Methods: In this study, 57 controls were tested for CSF biomarkers at baseline and then cognitively followed over 3 years. Results: Low levels of baseline beta-amyloid 1 - 42 (A beta 42) were associated with development of subjective memory impairment affecting quality of life (memQoL), with a worse Mini Mental Status Examination score and with inability to live in regular housing at follow-up ( p < 0.05). The combination of baseline A beta 42 and phosphorylated tau (P-tau) was found to predict development of pathological memQoL with a sensitivity of 71.4% and a specificity of 75.7 (< 0.01). Conclusion: Low A beta 42 and combined A beta 42 and P-tau predicted subjective cognitive decline in healthy individuals. In summary, this study shows that already in the clinically normal population Alzheimer-disease-related biological signs might be detectable. Copyright (c) 2007 S. Karger AG, Basel.