Altered fractional amplitude of low frequency fluctuation associated with cognitive dysfunction in first-episode drug-naïve major depressive disorder patients.
Altered fractional amplitude of low frequency fluctuation associated with cognitive dysfunction in first-episode drug-naïve major depressive disorder patients.
复制标题
首发药物重度抑郁症患者中与认知功能障碍相关的低频波动的分数幅度改变。
DOI：
10.1186/s12888-016-1190-1
复制
发表时间：
2017-01-11
期刊：
影响因子：
4.4
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Huang M;Lu S;Yu L;Li L;Zhang P;Hu J;Zhou W;Hu S;Wei N;Huang J;Weng J;Xu Y
以往的研究表明，抑郁症患者常伴有静息态脑活动异常和认知功能障碍。然而，这两个方面之间的潜在关系较少研究。在这种情况下，本研究的目的是调查首次发作的药物初治MDD患者的认知功能障碍和静息态脑功能改变之间的关联。本研究招募了25名药物初治MDD患者和26名年龄、性别和教育程度匹配的正常对照。通过使用一系列经验证的测试程序来评估认知功能。在Philips 3.0 Tesla扫描仪上获得静息态功能磁共振成像数据，并使用低频波动分数振幅（fALFF）方法进行分析。进一步分析fALFF值与认知功能障碍的相关性。与健康对照组相比，MDD患者在威斯康星州卡片分类测验（WCST）中完成的类别显著减少，在连续操作测验（CPT）的第一和第二子测验中得分降低。然而，两组在Stroop颜色词测试和线索制作测试中的表现没有差异。MDD患者在左额上级回（SFG）、左额中回和左额下回中表现出显著降低的fALFF值，而在左颞下回（ITG）、双侧海马旁回和右侧尾状核中表现出增加的fALFF值。最后，相关性分析显示，左SFG和左ITG的fALFF值分别与MDD中完成的WSCT类别数和CPT第二子测验得分相关。目前的研究结果表明，很少有证据表明，区域异常之间的关联，在休息状态下的脑功能和认知功能障碍的抑郁症。
Previous studies have demonstrated that abnormities of both resting-state brain activity and cognitive dysfunction are frequently observed in patients with major depressive disorder (MDD). However, the underlying relationship between these two aspects is less investigated. In this context, the aim of the present study was to investigate the association between cognitive dysfunction and altered resting-state brain function in first-episode drug-naïve MDD patients. Twenty-five drug-naïve MDD patients and twenty-six age-, sex-, and education-matched normal controls were recruited in this study. Cognitive function was evaluated by using a series of validated test procedures. The resting-state functional magnetic resonance imaging data were obtained on a Philips 3.0 Tesla scanner and analysed using the fractional amplitude of low frequency fluctuation (fALFF) method. Correlations of fALFF values with cognitive dysfunction were further analysed. Compared with healthy controls, MDD patients showed significantly fewer completed categories in the Wisconsin Card Sorting Test (WCST) and decreased scores in the first and second subtests of the Continuous Performance Test (CPT). However, the two groups did not differ in their performance on the Stroop Colour Word Test and Trail-making Test. MDD patients exhibited significantly decreased fALFF values in the left superior frontal gyrus (SFG), left middle frontal gyrus, and left inferior frontal gyrus, as well as increased fALFF values in the left inferior temporal gyrus (ITG), bilateral parahippocampal gyrus, and the right caudate. Finally, the correlation analyses revealed that fALFF values in the left SFG and left ITG were associated with the number of WSCT completed categories and scores on the second subtest of the CPT in MDD, respectively. The present findings suggest that there is little evidence of an association between regional abnormalities in resting-state brain function and cognitive deficits in MDD.