New role for ceramide in the pheromone response.
New role for ceramide in the pheromone response.
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神经酰胺在信息素反应中的新作用。
DOI：
10.1080/15384101.2016.1143271
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Hannun,YusufA
中科院分区：
文献类型：
--
作者：
Matmati,Nabil;Kitagaki,Hiroshi;Hannun,YusufA
神经酰胺是一种主要的生物活性鞘脂，在真核生物的许多细胞过程中，如细胞凋亡、炎症和应激反应中，一直是一种重要的调节剂。在酵母中，许多表型归因于神经酰胺和鞘脂代谢的一个或多个基因的缺失或突变。1这些包括寿命/衰老、氧化应激、线粒体功能、耐热性、耐药性、细胞周期、营养反应、细胞壁和形态。Villasmil等人在Cell Cycle第15（3）期发表的文章确立了神经酰胺作为交配特异性细胞周期停滞调节剂的重要性。鞘脂途径中的基因突变或缺失已经涉及交配因子生物学的调节。例如，编码丝氨酸棕榈酰转移酶（鞘脂生物合成中的第一种酶）的关键亚基的LCB 1的突变已显示阻断α-因子摄取（参考文献# 23 Villasmil等人）。在全基因组筛选中，已发现ISC 1、YDC 1和LCB 5在暴露于交配信息素后的Ca 2+摄取中存在缺陷，并提示其在高亲和力Ca 2+内流系统（HACS）的激活中起作用。2额外的全基因组筛选研究表明，缺失以下任何鞘脂相关基因，
Ceramide, a major bioactive sphingolipid, continues to emerge as an important regulator of many cell processes in eukaryotes such as apoptosis, inflammation, and stress responses. In yeast, many phenotypes are attributed to deletion or mutation of one or more genes of ceramide and sphingolipid metabolism. 1 These include life span/aging, oxidative stress, mitochondrial function, heat resistance, drug resistance, cell cycle, nutrient response, cell wall and morphology. The article by Villasmil et al in issue 15 (3) of Cell Cycle, establishes the importance of ceramide as a regulator of the mating-specific cell cycle arrest. Mutations or deletions in genes in the sphingolipid pathway have been already implicated in regulation of mating factor biology. For example, mutation of LCB1, which encodes for a critical subunit of serine palmitoyl transferase, the first enzyme in sphingolipid biosynthesis, has been shown to block a-factor uptake (Ref.# 23 Villasmil et al.). In a genome-wide screen, ISC1, YDC1 and LCB5, have been found defective in Ca2+ uptake following exposure to mating pheromone, with a suggested role in the activation of HACS (high affinity Ca2+ influx system). 2 Additional genome-wide screen studies showed that deletion of any of the following sphingolipid related genes,