PROTECTION OF GERM-FREE MICE FROM INFECTION BY HELICOBACTER-FELIS AFTER ACTIVE ORAL OR PASSIVE IGA IMMUNIZATION
PROTECTION OF GERM-FREE MICE FROM INFECTION BY HELICOBACTER-FELIS AFTER ACTIVE ORAL OR PASSIVE IGA IMMUNIZATION
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DOI：
10.1016/0264-410x(93)90309-l
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发表时间：
1993-04-01
期刊：
影响因子：
5.5
通讯作者：
NEDRUD, JG
中科院分区：
文献类型：
--
作者：
CZINN, SJ;CAI, A;NEDRUD, JG
幽门螺杆菌（Helicobacter pylori，Hp）感染与胃炎、溃疡和胃癌的发生有关。在一个H。猫，无菌小鼠感染模型，口服免疫与细菌抗原加霍乱毒素导致血清，胃和肠道抗H。猫的抗体滴度和对急性感染的保护。给予单克隆伊加抗H的小鼠。在初始攻击时的猫抗体也被保护免于感染。这些结果表明，口服疫苗可能是预防H。pylori感染人类
Helicobacter pylori infection of human gastric epithelium has been associated with gastritis, ulcers and gastric cancers. In an H. felis, germ-free mouse model of infection, oral immunization with bacterial antigens plus cholera toxin resulted in elevated serum, gastric and intestinal anti-H. felis antibody titres and protection from acute infection. Mice given monoclonal IgA anti-H. felis antibody at the time of initial challenge were also protected from infection. These results demonstrate that oral vaccination may be a feasible approach for the prevention of H. pylori infection of humans.