Hydroamination of Terminal Alkynes by Amines Catalyzed by Copper Heteropoly Salts: A Simple Approach Towards Imine Synthesis
Hydroamination of Terminal Alkynes by Amines Catalyzed by Copper Heteropoly Salts: A Simple Approach Towards Imine Synthesis
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铜杂多盐催化胺对末端炔烃的氢胺化：亚胺合成的简单方法
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
S. B. Halligudi
中科院分区：
文献类型：
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作者：
G. Shanbhag;K. Palraj;S. B. Halligudi
加氢胺化反应为合成烷基化胺及其衍生物提供了一条非常有吸引力的路线，而没有副产物形成。研究了不同廉价的杂多酸铜盐催化下，炔与芳胺的非均相分子间氢胺化反应。在杂多酸盐中，硅钨酸的铜盐表现出最高的活性。芳香胺的反应活性随碱性的增加而增加。非均相催化剂中的酸性对炔的氢胺化反应有促进作用。
The hydroamination reaction offers a very attractive route for the synthesis of alkylated amines and their de- rivatives with no byproduct formation. Heterogeneous intermolecular hydroamination reactions of alkynes with aromatic amines using different inexpensive copper salts of hetropolyacid catalysts were investigated. Among heteropoly salts, copper salts of silicotungstic acid showed highest activity. Reactivity of aromatic amines increased with increase in its ba- sicity. Acidity in heterogeneous catalyst can act as promoter in hydroamination of alkynes.