Expression of P2X2 and P2X3 receptors in the rat carotid sinus, aortic arch, vena cava, and heart, as well as petrosal and nodose ganglia
Expression of P2X2 and P2X3 receptors in the rat carotid sinus, aortic arch, vena cava, and heart, as well as petrosal and nodose ganglia
复制标题
DOI：
10.1007/s11302-011-9249-4
复制
发表时间：
2011-08
影响因子：
3.5
通讯作者：
Xianmin Song;Xiao-fei Gao;Dazhi Guo;Qiang Yu;W. Guo;Cheng He;G. Burnstock;Z. Xiang
中科院分区：
文献类型：
--
作者：
Xianmin Song;Xiao-fei Gao;Dazhi Guo;Qiang Yu;W. Guo;Cheng He;G. Burnstock;Z. Xiang
应用单、双标记免疫荧光技术，研究了大鼠主要循环系统压力感受器、结状神经节和岩神经节内P2 X2和P2 X3免疫反应阳性神经纤维终末和神经元胞体的分布规律和形态特征。颈动脉窦内可见高密度的P2 X2和P2 X3免疫反应阳性神经纤维终末。P2 X2和P2 X3免疫反应神经纤维终末也广泛分布在主动脉弓、心房、腔静脉和心室中。几乎所有P2 X2阳性神经纤维终末均为P2 X3受体阳性。P2 X2和P2 X3免疫反应阳性神经元体也检测到的结状神经节和岩神经节，这是P2 X2和P2 X3免疫反应阳性神经末梢的来源。P2 X2和P2 X3受体表达于同一神经节细胞。提示细胞外ATP可能通过颈动脉窦、主动脉弓、心房和腔静脉感觉受体的P2 X2和P2 X3受体以及P2 X2/3受体参与体循环血压的调节。
With single- and double-labeling immunofluorescence techniques, the distribution patterns and morphological characteristics of P2X2- and P2X3-immunoreactive nerve fiber terminals and neuronal bodies have been studied in the main circulatory system baroreceptors and the nodose and petrosal ganglia of rats. A high density of P2X2- and P2X3-immunoreactive nerve fiber terminals was detected in the carotid sinus. P2X2- and P2X3-immunoreactive nerve fiber terminals were also distributed widely in the aortic arch, atrium, vena cava, and ventricles. Almost all the P2X2-immunoreactive nerve fiber terminals were immunoreactive for P2X3receptors. P2X2- and P2X3-immunoreactive neuronal bodies were also detected in the nodose and petrosal ganglia, which are the sources of the P2X2- and P2X3-immunoreactive nerve terminals. P2X2and P2X3receptors were expressed in the same ganglionic neurons. These data indicate that extracellular ATP, via the homomeric P2X2and P2X3receptors, and heteromeric P2X2/3receptor in the sensory receptors of carotid sinus, aortic arch, atrium, and vena cava, may be involved in the regulation of systematic circulation blood pressure.