Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin.
Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin.
复制标题
DOI：
10.1186/s12990-015-0019-0
复制
发表时间：
2015-04-22
期刊：
影响因子：
3.3
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Ma XL;Zhang FX;Dong F;Bao L;Zhang X
高浓度辣椒素的单次应用已被用作持续性疼痛的镇痛治疗。然而，其有效性和潜在机制仍有待进一步的实验方法评估。本研究表明，辣椒素单次剂量依赖性地减轻了大鼠和小鼠的伤害性超敏反应，减少了背根神经节（DRG）小直径神经元的动作电位放电。辣椒素预处理可减少大鼠和小鼠短暂痛觉过敏后福尔马林诱导的急性有害行为。辣椒素的抑制作用是钙依赖的，由辣椒素受体（瞬时受体电位-1型）介导。我们进一步发现辣椒素对外周炎症和神经损伤引起的持续性伤害性超敏反应有抑制作用。因此，这些结果支持局部辣椒素对持续性疼痛的持久和抑制作用，以及辣椒素作为疼痛治疗的临床应用。
The single application of high-concentration of capsaicin has been used as an analgesic therapy of persistent pain. However, its effectiveness and underlying mechanisms remain to be further evaluated with experimental approaches. The present study provided evidence showing that the single application of capsaicin dose-dependently alleviated nociceptive hypersensitivity, and reduced the action potential firing in small-diameter neurons of the dorsal root ganglia (DRG) in rats and mice. Pre-treatment with capsaicin reduced formalin-induced acute nocifensive behavior after a brief hyperalgesia in rats and mice. The inhibitory effects of capsaicin were calcium-dependent, and mediated by the capsaicin receptor (transient receptor potential vanilloid type-1). We further found that capsaicin exerted inhibitory effects on the persistent nociceptive hypersensitivity induced by peripheral inflammation and nerve injury. Thus, these results support the long-lasting and inhibitory effects of topical capsaicin on persistent pain, and the clinic use of capsaicin as a pain therapy.
登录
查看更多内容
影响因子：
2.9
作者：
Irving, Gordon A.;Backonja, Miroslav;Vanhove, Geertrui F.
通讯作者：
Vanhove, Geertrui F.
影响因子：
4
作者：
Kennedy, William R.;Vanhove, Geertrui F.;Selim, Mona M.
通讯作者：
Selim, Mona M.
影响因子：
25
作者：
Chavez, Andres E.;Chiu, Chiayu Q.;Castillo, Pablo E.
通讯作者：
Castillo, Pablo E.
影响因子：
2.5
作者：
Liu, L;Simon, SA
通讯作者：
Simon, SA
影响因子：
48
作者：
Backonja, Miroslav;Wallace, Mark S.;Tobias, Jeffrey
通讯作者：
Tobias, Jeffrey