Regulatory Mechanisms of Vitellogenesis in Insects.
Regulatory Mechanisms of Vitellogenesis in Insects.
复制标题
昆虫卵黄发生的调节机制。
DOI：
10.3389/fcell.2020.593613
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发表时间：
2020
影响因子：
5.5
通讯作者：
Zhou S
中科院分区：
文献类型：
--
作者：
Wu Z;Yang L;He Q;Zhou S
卵黄发生是昆虫产卵和产卵后胚胎发育的先决条件。在昆虫卵黄发生过程中，卵黄蛋白前体卵黄蛋白原(VG)主要在脂肪体中合成，由血淋巴通过卵泡上皮的细胞间隙(通透性)到达成熟卵母细胞膜，并通过受体介导的内吞作用滞留到成熟卵母细胞中。昆虫卵黄发生受两种关键激素控制，即倍半萜保幼激素(JH)和蜕皮激素20-羟基蜕皮酮(20E)。JH作为主要的促性腺激素，刺激基本的半变态和大多数全变态昆虫的卵黄发生。20E在膜翅目、鳞翅目和双翅目昆虫的卵黄发生中起关键作用。此外，microRNA(MiRNA)和营养(氨基酸/雷帕霉素和胰岛素的靶标)途径与JH和20E信号级联作用，控制昆虫的卵黄发生。揭示昆虫卵黄发生的调控机制对于了解昆虫繁殖和开发新的害虫控制策略具有重要意义。本文就促性腺激素JH和20E的分子作用以及miRNA和营养感受器在调节昆虫卵黄发生中的作用等方面的最新研究进展作一综述。我们重点介绍了激素、miRNA和营养信号通路的协调作用在昆虫卵黄发生调控机制中的研究进展。
Vitellogenesis is pre-requisite to insect egg production and embryonic development after oviposition. During insect vitellogenesis, the yolk protein precursor vitellogenin (Vg) is mainly synthesized in the fat body, transported by the hemolymph through the intercellular spaces (known as patency) in the follicular epithelium to reach the membrane of maturing oocytes, and sequestered into the maturing oocytes via receptor-mediated endocytosis. Insect vitellogenesis is governed by two critical hormones, the sesquiterpenoid juvenile hormone (JH) and the ecdysteriod 20-hydroxyecdysone (20E). JH acts as the principal gonadotropic hormone to stimulate vitellogenesis in basal hemimetabolous and most holometabolous insects. 20E is critical for vitellogenesis in some hymenopterans, lepidopterans and dipterans. Furthermore, microRNA (miRNA) and nutritional (amino acid/Target of Rapamycin and insulin) pathways interplay with JH and 20E signaling cascades to control insect vitellogenesis. Revealing the regulatory mechanisms underlying insect vitellogenesis is critical for understanding insect reproduction and helpful for developing new strategies of insect pest control. Here, we outline the recent research progress in the molecular action of gonadotropic JH and 20E along with the role of miRNA and nutritional sensor in regulating insect vitellogenesis. We highlight the advancements in the regulatory mechanisms of insect vitellogenesis by the coordination of hormone, miRNA and nutritional signaling pathways.