Effect of low versus normal birthweight on menarche in 14-year-old Polish girls
Effect of low versus normal birthweight on menarche in 14-year-old Polish girls
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DOI：
10.1046/j.1440-1754.2002.00793.x
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发表时间：
2002-06-01
影响因子：
1.7
通讯作者：
Jankowska, EA
中科院分区：
文献类型：
--
作者：
Koziel, S;Jankowska, EA
目的：宫内发育迟缓与性成熟之间的关系尚未完全确定。本研究的目的是比较14岁波兰出生体重低和正常女孩的月经初潮，并评估社会经济地位和身体质量指数（BMI）的影响。方法：我们研究了年龄13.5-14.5岁的1060名女孩（初潮前177名，初潮后883名）。这些女孩在波兰弗罗茨瓦夫随机选择的小学上七年级。BMI被用来衡量一般的肥胖程度。用胎龄出生体重第10百分位数的临界值来区分出生时小于胎龄的女孩（SGA）和出生体重与胎龄合适的女孩（AGA）。采用父母教育水平等指标评价社会经济地位（SES）。结果：14岁时出生体重（OR = 2.54; 95%CI 1.22 ~ 5.28）和体重指数（OR = 7.93; 95%CI 4.67 ~ 13.48）是影响14岁女孩月经初潮发生的因素。结论：波兰出生时胎龄较小的女孩与出生时体重正常的同龄人相比，更有可能在14岁时经历月经初潮。这些发现似乎与一种假设相一致，即初潮的年龄在某种程度上是由出生前建立的促性腺激素释放模式决定的。此外，月经初潮的年龄取决于儿童和青少年时期的脂肪积累水平。
Objective: The relationship between intrauterine growth retardation and sexual maturation has not been completely established. The aim of the present study was to compare menarche in 14-year-old Polish girls of low and normal birthweight, along with an evaluation of the impact of socio-economic status and body mass index (BMI).Methods: We studied 1060 girls (177 pre- and 883 post-menarche) aged 13.5-14.5 years. These girls attended the 7th grade of randomly selected primary schools in Wroclaw, Poland. The BMI was used as a measurement of general adiposity. The cut-off value of the 10th percentile of birthweight for gestational age was used to differentiate between girls born small for gestational age (SGA) and girls with a birthweight appropriate to gestational age (AGA). Parental education level and other measures were used to assess socio-economic status (SES).Results: Birthweight (OR = 2.54; 95% CI 1.22-5.28) and BMI at the age of 14 years (OR = 7.93; 95%CI 4.67-13.48) were factors affecting the onset of menarche among the 14-year-old girls.Conclusion: Polish girls born small for gestational age are more likely to have experienced menarche by the age of 14 years, compared with their peers of normal weight at birth. These findings seem to be consistent with the hypothesis that the age of menarche is, to some extent, set by patterns of gonadotropin release, established prior to birth. Additionally, the age of menarche varies depending on levels of fat accumulation during childhood and adolescence.