Double dissociation of selective recollection and familiarity impairments following two different surgical treatments for temporal-lobe epilepsy
Double dissociation of selective recollection and familiarity impairments following two different surgical treatments for temporal-lobe epilepsy
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DOI：
10.1016/j.neuropsychologia.2010.05.010
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发表时间：
2010-07-01
期刊：
影响因子：
2.6
通讯作者：
Koehler, Stefan
中科院分区：
文献类型：
--
作者：
Bowles, Ben;Crupi, Carina;Koehler, Stefan
研究已经确定，内侧颞叶（MTL）的完整性对识别记忆至关重要。这种能力得到了回忆和熟悉度评估的支持，回忆涉及恢复过去刺激遭遇的背景细节，熟悉度评估导致意识到先前发生的事件而没有这种恢复。MTL组织的双加工模型表明，回忆和熟悉分别由海马和嗅周皮层支持。或者，有人认为，这两种结构支持这些识别过程类似的一个更完整的陈述性记忆系统的一部分，从这个角度来看，报告的选择性回忆障碍与限制海马病变可能反映了不同的敏感性整体记忆强度，而不是在一个独特的识别过程中的赤字。过去的神经心理学研究结果仍然不一致和有争议，部分原因是患者选择的偏见，临床病因的变异性和有限的病变记录。在这里，我们管理的言语记忆任务相结合的记住知道的判断，10个人谁经历了左侧或右侧立体定向杏仁核-海马campotomy手术治疗顽固性颞叶癫痫。与健康对照组的比较显示，无论半球病变部位如何，在保持熟悉性的情况下，孤立的记忆障碍。此外，我们表明，这种损害可以在相当水平的记忆强度（即，整体识别性能）作为选择性熟悉性损伤，我们以前在N.B. - 一名患者接受了定制的左前颞叶切除术，保留海马，以治疗颞叶癫痫。通过揭示一个双重分离颞叶机制的回忆和熟悉，这一证据反对一个单一的，基于强度的MTL组织的帐户。(C)2010爱思唯尔有限公司版权所有。
Research has firmly established that the integrity of the medial temporal lobe (MTL) is critical for recognition memory. This ability is supported by recollection, which involves recovery of contextual details of a past stimulus encounter, and familiarity assessment, which leads to awareness of prior occurrence without such recovery. Dual-process models of MTL organization posit that recollection and familiarity are supported by the hippocampus and perirhinal cortex, respectively. Alternatively, it has been argued that both structures support these recognition processes similarly as part of a more integrated declarative memory system; from this perspective, reported selective recollection impairments with circumscribed hippocampal lesions may reflect differential sensitivity to overall memory strength, rather than a deficit in a distinct recognition process. Findings from past neuropsychological research remain inconsistent and controversial, in part due to biases in patient selection, variability in clinical etiology, and limited lesion documentation. Here, we administered a verbal recognition-memory task in combination with remember-know judgements to 10 individuals who had undergone left- or right-sided stereotactic amygdalo-hippocampotomy as a surgical treatment for intractable temporal-lobe epilepsy. Comparisons with healthy control participants revealed isolated impairments in recollection with preserved familiarity, regardless of hemispheric site of lesion. In addition, we show that this impairment can be observed at a comparable level of memory strength (i.e., overall recognition performance) as the selective familiarity impairment we previously described in N.B. - an individual who underwent a tailored surgical resection of the left anterior temporal lobe with hippocampal sparing for treatment of temporal-lobe epilepsy. By revealing a double dissociation concerning temporal-lobe mechanisms for recollection and familiarity, this evidence argues against a unitary, strength-based account of MTL organization. (C) 2010 Elsevier Ltd. All rights reserved.