Prevalence of Allergic Rhinitis and Sensitization to Common Aeroallergens in a Japanese Population
Prevalence of Allergic Rhinitis and Sensitization to Common Aeroallergens in a Japanese Population
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DOI：
10.1159/000242363
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发表时间：
2010-01-01
影响因子：
2.8
通讯作者：
Fujieda, Shigeharu
中科院分区：
文献类型：
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作者：
Sakashita, Masafumi;Hirota, Tomomitsu;Fujieda, Shigeharu
背景：过敏性鼻炎（AR）被认为是全球范围内的一个主要健康问题，其患病率取决于研究对象的年龄范围。本研究的目的是确定日本受试者中AR的当前患病率、年龄对吸入性过敏原IgE致敏率的影响以及血清总IgE水平。
方法：我们在2006年和2007年对1540名20至49岁的受试者进行了一项调查，并检查了AR的患病率以及对7种常见气传过敏原的致敏情况。我们测量了血清总IgE以及针对7种气传过敏原的特异性IgE。AR是根据问卷调查中提到的由气传过敏原引起的主要在鼻和眼的症状以及通过测量血清特异性IgE评估的对7种气传过敏原中任何一种的致敏情况来确定的。
结果：AR的患病率为44.2%（1540名受试者中的681人），在各个年龄组之间没有差异。在1540名受试者中，1073人（69.7%）对7种气传过敏原中的至少一种致敏。在所有接受检查的年龄组中，AR中最常见的过敏原是日本柳杉花粉（89.6%，681名AR患者中的610人）。年轻受试者对螨虫的致敏率显著更高。
结论：我们的数据表明，在20至49岁之间，AR的患病率在过去10年中增加了近10%。在日本人群中，柳杉花粉和螨虫是7种气传过敏原中的主要过敏原来源。
版权所有（C）2009 S. Karger AG，巴塞尔
Background: Allergic rhinitis (AR) is recognized as a major health problem worldwide, and its prevalence depends on the age range of the subjects. The aims of this study were to determine the current prevalence of AR, effects of age on the prevalence of IgE sensitization to inhalant allergens, and serum total IgE levels in Japanese subjects. Methods: We conducted a survey of 1,540 subjects between 20 and 49 years of age in 2006 and 2007 and examined the prevalence of AR and sensitization to 7 common aeroallergens. We measured serum total IgE and specific IgE to 7 aeroallergens. AR was determined based on symptoms, predominantly in the nose and eyes, caused by aeroallergens as mentioned in a questionnaire and sensitization to any of the 7 aeroallergens as assessed by measurement of serum specific IgE. Results: The prevalence of AR was 44.2% (681 of the 1,540 subjects) and there was no difference among age decades. Of the 1,540 subjects, 1,073 (69.7%) were sensitized to at least 1 of the 7 aeroallergens. The most common allergen in AR was Japanese cedar pollen (89.6%, 610 of the 681 with AR) in all the age decades examined. The sensitization rate to mites was significantly higher in the younger subjects. Conclusion: Our data suggest that the prevalence of AR between 20 and 49 years of age has increased by nearly 10% during the last 10 years. Cedar pollen and mites were predominant allergen sources among the 7 aeroallergens in the Japanese population. Copyright (C) 2009 S. Karger AG, Basel