Association between insulin resistance, cardiovascular risk factors and overweight in Japanese schoolchildren
Association between insulin resistance, cardiovascular risk factors and overweight in Japanese schoolchildren
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DOI：
10.1016/j.orcp.2011.04.002
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发表时间：
2012-01-01
影响因子：
4.3
通讯作者：
Sakakibara, Hisataka
中科院分区：
文献类型：
--
作者：
Fujii, Chie;Sakakibara, Hisataka
目的：本研究的目的是探讨胰岛素抵抗，心血管危险因素和超重之间的关联在日本学龄儿童。方法：进行了一项横断面研究，对310名小学生（155名男孩和155名女孩）的五年级和八年级在日本长野县的一个城镇。结果：HbA 1c和空腹血糖与BMI无相关性，但超重组空腹胰岛素和HOMA-IR显著高于BMI最低组。在超重组中，HOMA-IR的均值和标准差为2.51 ± 1.01，HOMA-IR ≥ 2.5的患病率为46.8%。HOMA-IR >= 2.5的学龄儿童有更多的心血管危险因素。结论：超重的日本儿童存在胰岛素抵抗，尽管他们的血红蛋白A1 c和空腹血糖在正常范围内。此外，随着BMI的增加，心血管危险因素的数量也增加。体重管理应该从童年开始。(C)2011年亚洲大洋洲肥胖研究协会。由爱思唯尔有限公司出版。保留所有权利。
Objective: The aim of this study was to examine the association between insulin resistance, cardiovascular risk factors and overweight in Japanese schoolchildren.Methods: A cross-sectional study was performed on 310 schoolchildren (155 boys and 155 girls) of the fifth grade and the eighth grade in a town in Nagano Prefecture, Japan. The survey was conducted on anthropometric, blood examinations, and by calculation of body mass index (BMI: body weight/body height(2)) and HOMA-IR (fasting insulin x fasting glucose/405).Results: Hemoglobin A1c and fasting glucose were not associated with BMI, whereas fasting insulin and HOMA-IR were significantly higher in overweight children in comparison with the lowest quartile BMI group. In the overweight, the mean and standard deviation of HOMA-IR were 2.51 +/- 1.01, and the prevalence of HOMA-IR >= 2.5 was 46.8%. Schoolchildren with HOMA-IR >= 2.5 had more several cardiovascular risk factors.Conclusions: Insulin resistance was observed in overweight Japanese children, though their hemoglobin A1c and fasting glucose were within the normal range. In addition, with higher BMI, the number of cardiovascular risk factors was increased. Weight management should be started in childhood. (C) 2011 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.