Ecalectin/galectin-9, a novel eosinophil chemoattractant: Its function and production
Ecalectin/galectin-9, a novel eosinophil chemoattractant: Its function and production
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DOI：
10.1159/000053623
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发表时间：
2000-01-01
影响因子：
2.8
通讯作者：
Hirashima, M
中科院分区：
文献类型：
--
作者：
Hirashima, M
我们最近成功地纯化和克隆了一种新的嗜酸性粒细胞化学引诱物，ecalectin/galectin-9，它属于一个快速增长的galectin家族。ecalectin的嗜酸性粒细胞化学引诱活性对嗜酸性粒细胞具有强效和选择性。ecalectin的细胞来源被认为是抗原刺激的T细胞。在此，我们将综述其二价半乳糖苷结合活性在ecalectin诱导的嗜酸性粒细胞化学吸引和免疫细胞中ecalectin表达的调节中的意义。版权所有（C）2000 S. Karger AG，巴塞尔。
We have recently succeeded in purifying and cloning a novel eosinophil chemoattractant, ecalectin/galectin-9, which belong to a rapidly growing galectin family. The eosinophil chemoattractant activity of ecalectin is potent and selective for eosinophils. The cellular source of ecalectin has been thought to be antigen-stimulated T cells. Herein, we will review the significance of its divalent galactoside-binding activity in ecalectin-induced eosinophil chemoattraction and the regulation of ecalectin expression in immune cells. Copyright (C) 2000 S. Karger AG, Basel.