Effect of social rank on brain monoaminergic activity in a cichlid fish.
Effect of social rank on brain monoaminergic activity in a cichlid fish.
复制标题
社会等级对慈鲷大脑单胺能活动的影响。
DOI：
10.1159/000112994
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Fernald,RD
中科院分区：
文献类型：
--
作者：
Winberg,S;Winberg,Y;Fernald,RD
在非洲的一种鱼中，雄性性成熟是通过社会互动来调节的，而这些影响是由大脑视前区含有促性腺激素释放激素（GnRH）的神经元介导的。由于已知脑单胺能系统参与GnRH释放的调节，并且这些系统的活性受到激动相互作用的影响，我们分析了社会地位对脑单胺能活性的影响。burtoni。动物要么(1)在正常的社会群体中由两只雄性和四只雌性组成，要么(2)在一只雄性和五只雌性的群体中。对每组动物进行定量行为观察，并在献祭后进行几项生理测量。测定血清素（5-HT）、5-羟基吲哚乙酸（5-HIAA， 5-HT的主要代谢物）、色氨酸（5-HT的氨基酸前体）、多巴胺（DA）和3,4 -二羟基苯基乙酸（DOPAC， DA的主要代谢物）的浓度。计算5-HIAA/5-HT和DOPAC/DA比值，分别作为5-HT和DA活性的指标。此外，性腺-躯体指数由体重和性腺重量计算，作为生殖状态的指标。无领地雄性脑干的5-HIAA浓度和5-HLAA/5-HT比值显著高于领地雄性，在脑端和下丘脑也有类似的趋势。此外，在非领地雄性中，端脑和脑干中的TRP浓度明显较低。该物种雌性性成熟不受社会调控，拮抗行为与生物化学指标之间无显著相关性。这些结果表明，男性和女性的神经化学反应存在根本差异。burtoni。
InHaplochromis burtoni,an African cichlid fish, male sexual maturation is regulated via social interactions, and these effects are mediated by gonadotropin-releasing-hormone (GnRH)-containing neurons in the preoptic area of the brain. Since brain monoaminergic systems are known to be involved in the regulation of GnRH release, and the activity of these systems is influenced by agonistic interactions, we analyzed the effect of social status on brain monoaminergic activity inH. burtoni.Animals were either (1) in normal social groups consisting of two males and four females or (2) in groups of one male and five females. Quantitative behavioral observations were made on each group of animals and, following sacrifice several physiological measurements were made. Concentrations of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA, the main 5-HT metabolite) and tryptophan (TRP, the amino acid precursor of 5-HT), dopamine (DA) and 3, 4-dihydroxyphenylacetic acid (DOPAC, the main DA metabolite) were measured. The 5-HIAA/5-HT and DOPAC/DA ratios were calculated and used as indexes of 5-HT and DA activity, respectively. In addition, the gonado-somatic index was calculated from body and gonadal weights and used as an index of reproductive status. Concentrates of 5-HIAA as well as 5-HLAA/5-HT ratios were significantly higher in brainstem of non-territorial males than in that of territorial males, and similar trends were seen in the telencephalon and hypothalamus. Moreover, TRP concentrations in the telencephalon and brainstem were significantly lower in non-territorial males. In this species, sexual maturation in females is not socially regulated, and there was no significant correlation between measured antagonistic behavior and biochemical indices. These results suggest a fundamental difference in the neurochemical responses between male and femaleH. burtoni.