Familial tumor syndrome associated with a germline nonfunctional p16INK4a allele.

Familial tumor syndrome associated with a germline nonfunctional p16INK4a allele.
复制标题

与种系无功能 p16INK4a 等位基因相关的家族性肿瘤综合征。

DOI:
10.1093/jnci/88.20.1489
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发表时间:
1996
期刊:
Journal of the National Cancer Institute
影响因子:
--
通讯作者:
Liu,ET
Liu,ET
中科院分区:
--
文献类型:
--
作者:
Yarbrough,WG;Aprelikova,O;Pei,H;Olshan,AF;Liu,ET

文献摘要

被引文献

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讨论了一个有缺陷的p16INK4a肿瘤抑制基因与宿主的体细胞和家族性肿瘤的关联。家族性肿瘤早期检测的意义:P16可能是生殖系遗传缺陷的位点
Discusses the association of a defective p16INK4a tumor suppressor gene with a host of somatic and familial tumors. Implications for the early detection of familial tumors; P16 as possible locus of germline genetic defects.