Deep-UV Surface-Enhanced Resonance Raman Scattering of Adenine on Aluminum Nanoparticle Arrays
Deep-UV Surface-Enhanced Resonance Raman Scattering of Adenine on Aluminum Nanoparticle Arrays
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DOI：
10.1021/ja210446w
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发表时间：
2012-02-01
影响因子：
15
通讯作者：
Loeffler, Joerg F.
中科院分区：
文献类型：
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作者：
Jha, Shankar K.;Ahmed, Zeeshan;Loeffler, Joerg F.
我们报道了在铝纳米结构上使用深紫外表面增强共振拉曼散射对腺嘌呤的超灵敏检测。利用极紫外干涉光刻技术在大面积上制备了定义良好的铝纳米颗粒阵列，在紫外和深紫外波长范围内表现出尖锐和可调谐的等离子体共振。基于时域有限差分方法建立理论模型，了解纳米粒子阵列的近场和远场光学特性。在激光激发波长为257.2 nm的条件下，对均匀涂覆在Al纳米粒子阵列上的腺嘌呤分子进行了拉曼测量。使用这种技术，可以实时检测不到10amol的无标记腺嘌呤分子。Zeptomole（类似于30,000个分子）的检测灵敏度很容易达到，证明深紫外表面增强共振拉曼散射是一种非常敏感的生物分子检测工具。
We report the ultrasensitive detection of adenine using deep-UV surface-enhanced resonance Raman scattering on aluminum nanostructures. Well-defined Al nanoparticle arrays fabricated over large areas using extreme-UV interference lithography exhibited sharp and tunable plasmon resonances in the UV and deep-UV wavelength ranges. Theoretical modeling based on the finite-difference time-domain method was used to understand the near-field and far-field optical properties of the nanoparticle arrays. Raman measurements were performed on adenine molecules coated uniformly on the Al nanoparticle arrays at a laser excitation wavelength of 257.2 nm. With this technique, less than 10 amol of labelfree adenine molecules could be detected reproducibly in real time. Zeptomole (similar to 30 000 molecules) detection sensitivity was readily achieved proving that deep-UV surface-enhanced resonance Raman scattering is an extremely sensitive tool for the detection of biomolecules.